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Aging and disease    2018, Vol. 9 Issue (2) : 228-234     DOI: 10.14336/AD.2017.0415
Orginal Article |
Brain Interstitial Fluid Drainage Alterations in Glioma-Bearing Rats
Guan Xiangping1,2, Wang Wei1,2, Wang Aibo1,2, Teng Ze1,2, Han Hongbin1,2,*
1Department of Radiology, Peking University Third Hospital, Beijing 100191, China
2Beijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China
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Abstract  

Real time imaging and measurement of the drug distribution in the brain interstitial space (ISS) are able to determine the effeicency of local brain drug delivery to treatment gliomas. In the present study, we used a tracer-based magnetic resonance imaging (MRI) method to quantitatively analyze the effects of glioma growth on ISF drainage. Sprague-Dawley rats were randomly divided into six groups (n = 6). C6 glioma cells were implanted into either the caudate nucleus or thalamus of rats and then were examined 10 or 20 days after implantation. The two control groups were treated with vehicle. A tracer was injected into the caudate nucleus of control rats and rats with gliomas growing in the thalamus for 10 or 20 days. The tracer was similarly injected into the thalamus of control rats and rats implanted with gliomas in the caudate nucleus. The diffusion and clearance parameters of the tracer were calculated using tracer-based MRI techniques. We found that glioma implanted in the caudate nucleus significantly decreased the speed of the ISF flow in thalamus. With the growth of the glioma in thalamus, the drainage route of the brain ISF flow was altered in the caudate nucleus, but the speed of the flow was not significantly changed. These findings indicate that tracer-based MRI is a promising technique for optimizing the interstitial administration of therapeutics aimed at treating brain gliomas.

Keywords MRI      Gd-DTPA      glioma      interstitial fluid     
Corresponding Authors: Han Hongbin   
About author:

These authors contributed equally to this work.

Issue Date: 01 April 2018
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Guan Xiangping
Wang Wei
Wang Aibo
Teng Ze
Han Hongbin
Cite this article:   
Guan Xiangping,Wang Wei,Wang Aibo, et al. Brain Interstitial Fluid Drainage Alterations in Glioma-Bearing Rats[J]. Aging and disease, 2018, 9(2): 228-234.
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http://www.aginganddisease.org/EN/10.14336/AD.2017.0415     OR     http://www.aginganddisease.org/EN/Y2018/V9/I2/228
Figure 1.  MRI images of gliomas in the caudate nucleus and thalamus of control groups and 10 and 20 days after implantation. Images acquired using T2WI of control groups and 10 and 20 days after implantation (A). Volume of the gliomas of control groups and 10 and 20 days after implantation (B). Tumor volume significantly increased from 10 to 20 days after implantation (C). ***P<0.05.
Figure 2.  Gd-DTPA distribution in the caudate nucleus of control group and of the 10-day tumor (thalamus) group in axial plane (a), sagittal plane (b) and coronal plane (c). A) normal control group; B) the 10-day tumor (thalamus) group.
Figure 3.  Gd-DTPA distribution in the caudate nucleus outside of the tumor (thalamus) in the 20-day group. A) axial plane; B) sagittal plane; C) coronal plane.
Figure 4.  Gd-DTPA distribution in thalamus in the axial plane. A) normal control group; B) 10-day glioma in the caudate nucleus; C) 20-day glioma in the caudate nucleus.
Figure 5.  Thalamic Tenascin-C expression in control group and in the rats with glioma for 10-day and 20-day. Tenascin-C expression in thalamus of control group (A). Tenascin-C expression in thalamus of rats with glioma for 10-day (B). Tenascin-C expression in thalamus of rats with glioma for 20-day (C). Arrow identify the location of tenascin-C expression. Scale bar, 100 μm.
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