Aging and disease

Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals Cyrus A. Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Kellyann Niotis, David A. Merrill, Rajpaul Attariwala: | DOI: 10.14336/AD.2023.0820; PDF (1477KB)

Rapidly Progressive Dementia with Asymmetric Rigidity Following ChAdOx1 nCoV-19 Vaccination Sankha Shubhra Chakrabarti, Ashutosh Tiwari, Sumit Jaiswal, Upinder Kaur, Ishan Kumar, Amit Mittal, Anup Singh, Kunlin Jin, Sasanka Chakrabarti: 2022, 13 (3): 633-636 | DOI: 10.14336/AD.2021.1102; PDF (363KB)

DeepMAge: A Methylation Aging Clock Developed with Deep Learning Fedor Galkin, Polina Mamoshina, Kirill Kochetov, Denis Sidorenko, Alex Zhavoronkov: 2021, 12 (5): 1252-1262 | DOI: 10.14336/AD.2020.1202; PDF (742KB)
Supplement; 1. Supplementary data.pdf (2088KB)

New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases Yu-Qing Ni, You-Shuo Liu: 2021, 12 (8): 1948-1963 | DOI: 10.14336/AD.2021.0603; PDF (645KB)

Metabolic Strategies in Healthcare: A New Era Matthew CL Phillips: 2022, 13 (3): 655-672 | DOI: 10.14336/AD.2021.1018; PDF (855KB)

Transcranial Near Infrared Light Stimulations Improve Cognition in Patients with Dementia Damir Nizamutdinov, Xiaoming Qi, Marvin H Berman, Gordon Dougal, Samantha Dayawansa, Erxi Wu, S. Stephen Yi, Alan B Stevens, Jason H Huang: 2021, 12 (4): 954-963 | DOI: 10.14336/AD.2021.0229; PDF (459KB)

Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging Sajid Ur Rahman, Abdul Qadeer, Ziyun Wu: 2024, 15 (2): 565-583 | DOI: 10.14336/AD.2023.0519-1; PDF (1183KB)

Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives Juan Liu, Yuzhu Tan, Hao Cheng, Dandan Zhang, Wuwen Feng, Cheng Peng: 2022, 13 (4): 1106-1126 | DOI: 10.14336/AD.2022.0104; PDF (1455KB)

Comparative Analysis of Aducanumab, Zagotenemab and Pioglitazone as Targeted Treatment Strategies for Alzheimer’s Disease Morteza Abyadeh, Vivek Gupta, Veer Gupta, Nitin Chitranshi, Yunqi Wu, Ardeshir Amirkhani, Anna Meyfour, Samran Sheriff, Ting Shen, Kunal Dhiman, Ghasem H. Salekdeh, Paul A. Haynes, Stuart L. Graham, Mehdi Mirzaei: 2021, 12 (8): 1964-1976 | DOI: 10.14336/AD.2021.0719; PDF (536KB)

Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases Ziying Jiang, Xi Yin, Miao Wang, Tong Chen, Yuanyuan Wang, Zhongbao Gao, Zhenfu Wang: 2022, 13 (4): 1146-1165 | DOI: 10.14336/AD.2021.1217; PDF (808KB)

Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors Jing She, Rui Sheng, Zheng-Hong Qin: 2021, 12 (8): 1879-1897 | DOI: 10.14336/AD.2021.0523; PDF (621KB)

Pathogeneses and Imaging Features of Cerebral White Matter Lesions of Vascular Origins Xiaoqin Wu, Jingyuan Ya, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng: 2021, 12 (8): 2031-2051 | DOI: 10.14336/AD.2021.0414; PDF (1249KB)

Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management Batool F Kirmani, Katherine Au, Lena Ayari, Marita John, Padmashri Shetty, Robert J Delorenzo: 2021, 12 (4): 1097-1119 | DOI: 10.14336/AD.2021.0302; PDF (598KB)

Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota? Baiyun Wu, Jiai Yan, Ju Yang, Yanping Xia, Dan Li, Feng Zhang, Hong Cao: 2022, 13 (4): 1005-1014 | DOI: 10.14336/AD.2022.0117; PDF (535KB)

Concerns about Diuretics as the First-line Treatment of Hypertension in the Elderly Gang Li, Rui Hu: 2021, 12 (7): 1541-1542 | DOI: 10.14336/AD.2021.0224; PDF (226KB)

Exercise in Aging: Be Balanced Joanna Gronek, Michał Boraczyński, Piotr Gronek, Dariusz Wieliński, Jacek Tarnas, Sławomir Marszałek, Yi-Yuan Tang: 2021, 12 (5): 1140-1149 | DOI: 10.14336/AD.2021.0107; PDF (639KB)

Premature Senescence of T-cells Favors Bone Loss During Osteolytic Diseases. A New Concern in the Osteoimmunology Arena Luis González-Osuna, Alfredo Sierra-Cristancho, Carolina Rojas, Emilio A Cafferata, Samanta Melgar-Rodríguez, Angélica M Cárdenas, Rolando Vernal: 2021, 12 (5): 1150-1161 | DOI: 10.14336/AD.2021.0110; PDF (1165KB)

Identifying Dynamic Patterns of Polypharmacy for Patients with Dementia from Primary Care Electronic Health Records: A Machine Learning Driven Longitudinal Study Elisabetta Longo, Bruce Burnett, Sarah Bauermeister, Shang-Ming Zhou: 2023, 14 (2): 548-559 | DOI: 10.14336/AD.2022.0829; PDF (732KB)
Supplement; 1. Supplementary data.pdf (1432KB)

Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity Cyril Statzer, Ji Young Cecilia Park, Collin Y Ewald: 2023, 14 (3): 670-693 | DOI: 10.14336/AD.2022.1116; PDF (1130KB)

Irreversibility of Pulmonary Fibrosis Qing Yang Yu, Xiao Xiao Tang: 2022, 13 (1): 73-86 | DOI: 10.14336/AD.2021.0730; PDF (691KB)

Melatonin as an Antioxidant Agent in Stroke: An Updated Review Junjie Wang, Shiqi Gao, Cameron Lenahan, Yichen Gu, Xiaoyu Wang, Yuanjian Fang, Weilin Xu, Haijian Wu, Yuanbo Pan, Anwen Shao, Jianmin Zhang: 2022, 13 (6): 1823-1844 | DOI: 10.14336/AD.2022.0405; PDF (679KB)

cGAS- Stimulator of Interferon Genes Signaling in Central Nervous System Disorders Fengjuan Li, Ningqun Wang, Yangmin Zheng, Yumin Luo, Yongbo Zhang: 2021, 12 (7): 1658-1674 | DOI: 10.14336/AD.2021.0304; PDF (1087KB)

Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal Alba M Garcia-Serrano, Adélaïde A Mohr, Juliette Philippe, Cecilia Skoug, Peter Spégel, João M.N Duarte: 2022, 13 (1): 267-283 | DOI: 10.14336/AD.2021.0720; PDF (1307KB)
Supplement; 1. Supplementary data.pdf (119KB)

Roles of Ependymal Cells in the Physiology and Pathology of the Central Nervous System Shiyu Deng, Lin Gan, Chang Liu, Tongtong Xu, Shiyi Zhou, Yiyan Guo, Zhijun Zhang, Guo-Yuan Yang, Hengli Tian, Yaohui Tang: 2023, 14 (2): 468-483 | DOI: 10.14336/AD.2022.0826-1; PDF (754KB)

Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction Alejandra Romero, Pilar Dongil, Inés Valencia, Susana Vallejo, Álvaro San Hipólito-Luengo, Guillermo Díaz-Araya, José L Bartha, María M González-Arlanzón, Fernando Rivilla, Fernando de la Cuesta, Carlos F Sánchez-Ferrer, Concepción Peiró: 2022, 13 (1): 284-297 | DOI: 10.14336/AD.2021.0617; PDF (1545KB)
Supplement; 1. Supplementary data.pdf (503KB)

Depression and Dementia in Older Adults: A Neuropsychological Review Syuichi Tetsuka: 2021, 12 (8): 1920-1934 | DOI: 10.14336/AD.2021.0526; PDF (543KB)

SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases Zhenyang Guo, Peng Li, Junbo Ge, Hua Li: 2022, 13 (6): 1787-1822 | DOI: 10.14336/AD.2022.0413; PDF (2013KB)
Supplement; 1. Supplementary data.pdf (527KB)

Mammalian AKT, the Emerging Roles on Mitochondrial Function in Diseases Xiaoxian Xie, Ruonan Shu, Chunan Yu, Zhengwei Fu, Zezhi Li: 2022, 13 (1): 157-174 | DOI: 10.14336/AD.2021.0729; PDF (625KB)

Cellular Senescence in Cardiovascular Diseases: A Systematic Review Can Hu, Xin Zhang, Teng Teng, Zhen-Guo Ma, Qi-Zhu Tang: 2022, 13 (1): 103-128 | DOI: 10.14336/AD.2021.0927; PDF (883KB)

Molecular mechanisms of phase separation and amyloidosis of ALS/FTD-linked FUS and TDP-43 Jianxing Song: | DOI: 10.14336/AD.2023.1118; PDF (2054KB)

Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation Yaqun Huang, Ming-Xia Ge, Yu-Hong Li, Jing-Lin Li, Qin Yu, Fu-Hui Xiao, Hong-Shun Ao, Li-Qin Yang, Ji Li, Yonghan He, Qing-Peng Kong: 2023, 14 (4): 1374-1389 | DOI: 10.14336/AD.2022.1217; PDF (1647KB)
Supplement; 1. Supplementary data.pdf (633KB)

Skeletal Muscle Metabolic Alternation Develops Sarcopenia Qiumei Yang, Piu Chan: 2022, 13 (3): 801-814 | DOI: 10.14336/AD.2021.1107; PDF (698KB)

TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis Li-Li Ren, Hua Miao, Yan-Ni Wang, Fei Liu, Ping Li, Ying-Yong Zhao: 2023, 14 (5): 1633-1650 | DOI: 10.14336/AD.2023.0222; PDF (1084KB)

A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice Chenghao Jin, Yijie Shao, Xiaotao Zhang, Jiani Xiang, Ruize Zhang, Zeyu Sun, Shuhao Mei, Jingyi Zhou, Jianmin Zhang, Ligen Shi: 2021, 12 (8): 2125-2139 | DOI: 10.14336/AD.2021.0520; PDF (2051KB)
Supplement; 1. Supplementary data.pdf (1992KB)

Therapeutic Potential of Nucleic Acids when Combined with Extracellular Vesicles Brian Jurgielewicz, Steven Stice, Yao Yao: 2021, 12 (6): 1476-1493 | DOI: 10.14336/AD.2021.0708; PDF (704KB)

Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease Xiao-hang Qian, Ru-yan Xie, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang: 2022, 13 (4): 1252-1266 | DOI: 10.14336/AD.2021.1215; PDF (642KB)

The Role of SGLT2 Inhibitors in Vascular Aging Le Liu, Yu-Qing Ni, Jun-Kun Zhan, You-Shuo Liu: 2021, 12 (5): 1323-1336 | DOI: 10.14336/AD.2020.1229; PDF (737KB)

The Aged Intestine: Performance and Rejuvenation Qiwen Wang, Yadong Qi, Weiyi Shen, Jilei Xu, Lan Wang, Shujie Chen, Tongyao Hou, Jianmin Si: 2021, 12 (7): 1693-1912 | DOI: 10.14336/AD.2021.0202; PDF (1051KB)

Regulatory T cells in COVID-19 Huan Wang, Zhao Wang, Wen Cao, Qianqian Wu, Yujia Yuan, Xiangjian Zhang: 2021, 12 (7): 1545-1553 | DOI: 10.14336/AD.2021.0709; PDF (481KB)

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