Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging
Minjun Wang, Jiajia Chen, Fei Chen, Qinggui Liu, Yu Sun, Chen Yan, Tao Yang, Yiwen Bao, Yi-Ping Hu
Table 1 Rejuvenation of tissue-specific stem cells via therapeutic molecules on their niche.
Intervening approachTarget cellMechanismRejuvenation on functionReferences
Fgfr1 inhibitor SU5402 or Spry1 overexpressionMuSCsreducing FGF signalingloss of quiescence, regenerative capacity[24]
Fibronection injectionMuSCsrescue FAK signalingproliferative and myogenic potential[78]
TS2/16MuSCsactivation of β1-integrin/FGFRregenerative capacity[17]
Tyr AG 490MuSCsinhibition of JAK/STATsatellite cell number; self-renewal; regenerative capacity[70]
5,15 diphenylporphrineMuSCsinhibition of JAK/STATsatellite cell number; self-renewal; regenerative capacity[70]
Sodium salicylateMuSCsinhibition of NF-κB signalingregenerative capacity[79]
SB-505124NSCsblockade of TGFβ signalingproliferation of stem cells; neurogenesis[82]
Lateral ventricle choroid plexus (LVCP) secretomeNSCsunknownproliferation, self-renewal, and differentiation[32]
Loss of Dkk1NSCsincrease of Wnt activityself-renewal; number of neuronal progenitors; neurogenesis[83]
Rantes knockoutHSCsdecreased mTOR activitymyeloid skewing; engraftment potential[80]
Inactivation of the gene encoding Fbxw7HSCsactivation of Notch signalingHSCs numbers[81]