Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging
Minjun Wang, Jiajia Chen, Fei Chen, Qinggui Liu, Yu Sun, Chen Yan, Tao Yang, Yiwen Bao, Yi-Ping Hu
Table 2 Intervention in systemic environment to rejuvenate function of tissue-specific stem cells.
Intervening approachTarget cellMechanismRejuvenation on functionReferences
Frizzled-related protein 3 (sFRP3) incubationMuSCssuppression of Wnt signalingproliferative potential; muscle regeneration[22]
Dickkopf-1 (Dkk1) injectionMuSCssuppression of Wnt signalingmuscle regeneration[22]
TGF-beta receptor kinase inhibitorMuSCsattenuating TGFβ signllingregenerative potential[21]
Recombinant GDF11 injectionMuSCsunknownregenerative potential[35]
OxytocinMuSCsactivation of MAPK/ERK signalingMuSC activation and proliferation; regenerative potential[91]
Recombinant GDF11 injectionNSCsactivation of TGFβ signalingself-renewal; differentiation potential; neurogenesis[36]
GnRH I injectionNSCsunknownneuronesis; cognitive function[87]
CCL11-specific neutralizing antibodyNSCsunknownneuronesis; cognitive function[37]
N-acetylcysteine incubationMSCsScavenging reactive oxygen species (ROS)aging phenotypes[85]
4-hydroxytamoxifen (4-OHT) injectionSkinblockade of NF-κBage-associated gene expression; proliferation[86]
Recombinant GDF11 injectionRenal Epithelial cellUpregulating ERK1/2 pathwayproliferative capacity; renal repair[93]