Glucocerebrosidase mRNA is Diminished in Brain of Lewy Body Diseases and Changes with Disease Progression in Blood
Perez-Roca Laia, Adame-Castillo Cristina, Campdelacreu Jaume, Ispierto Lourdes, Vilas Dolores, Rene Ramon, Alvarez Ramiro, Gascon-Bayarri Jordi, Serrano-Munoz Maria A., Ariza Aurelio, Beyer Katrin
Table 3 Clinical characteristics of DLB and PD patients in the disease onset and duration groups.
DLB
Disease onset<65 years>65 yearsP1
n614
age at onset (range)61.4 (59-65)68.5 (66-74)n.p.2
age (range)67.6 (63-71)73.8 (69-80)n.p.
duration (range)6.2 (2-10)4.9 (2-10)0.135
male: female ratio1: 0.331: 0.40.765
Disease duration since onset<6 years>6 years
n137
age at onset (range)67.1 (59-74)63.5 (60-67)0.238
age (range)70.8 (63-80)72.8 (70-77)0.302
male:female ratio1: 0.51: 0.250.097
PD
Disease onset<65 years>65 years
n1214
age at onset (range)62.2 (60-64)70.0 (68-73)n.p.
age (range)69.0 (61-75)72.5 (68-75)n.p.
duration (range)6.8 (1-14)2.5 (0-6)0.015
male: female ratio1: 0.81:010.827
Disease duration since onset<6 years>6 years
n1511
age at onset (range)66.9 (60-73)61.7 (60-64)0.105
age (range)69.6 (61-75)72.3 (68-75)0.376
male: female ratio1: 0.91: 0.91