Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence
Zhang Zheng, Zhang Linlei, Ding Yuchuan, Han Zhao, Ji Xunming
Table 1 summary of the second neuroprotective strategies combined with hypothermia in ischemic stroke.
Main Function of combined strategiesCombined strategiesSpecified treatment
Reduce energy consumptionAnestheticsMethohexital
Thiopentone sodium Xenon Dexmedetomidine
Psychotropic agentsChlorpromazine and promethazine
Suppress calcium overloadNMDA receptor antagonists
Ryanodine receptor inhibitor
Dextromethorphan
MK-801 Delfotel Magnesium with or without tirilazad Dantrolene
Increase blood supplyReperfusion
Vessel dilator Induce arteriogenesis
t-PA
Intra-arterial recanalization Statin Granulocyte colony stimulating factor (G-CSF)
Anti-inflammationAntibioticsTacrolimus
Minocycline
Anti-oxidative stressOxidative stress scavengersEdaravone
Mannitol
Repair damaged cellsBiosynthesis of cell componentCiticoline
Increase oxygen supplyOxygenNormobaric oxygen
Hyperbaric oxygen
Reduce intracranial pressure-Decompressive craniectomy
Anti-apoptosisAnti-apoptosis proteinFNK protein
Gene of anti-apoptosis proteinBcl-2 gene
Multiple protection-Caffeinol (caffeine and ethanol)
Insulin-like growth factor-1 (IGF-1) Brain-derived neurotrophic factor (BDNF) Albumin