Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence
Zhang Zheng, Zhang Linlei, Ding Yuchuan, Han Zhao, Ji Xunming
Table 2 Summary of outcomes of neuroprotective treatments combined with therapeutic hypothermia in ischemic stroke.
ReferencePermanent(P)/
Transient (T) Ischemia
Temperature degree(°C)Combined TreatmentAim of studyYes/No
Animal
[10]P33Mk-801Enhanced effectNo
[11]T30Mk-801EffectiveYes
[12]T30Mk-801Enhanced effectYes
[18]T34SelfotelEnhanced effectNo
[19]Repetitive34SelfotelEnhanced effectYes
[21]T35.4MagnesiumEnhanced effectYes
[22]P35MagnesiumEnhanced effectYes
[23]T33-34MagnesiumEnhanced effectYes
[24]P35MagnesiumEnhanced effectNo
[27]T33t-PAReduce the side effect of t-PAYes
[28]T34t-PAReduce the side effect of t-PAYes
[29]T32Delayed t-PAEnhanced effectNo
[30]T33t-PAEnhanced effectNo
[42]T35TacrolimusEnhancec/expand time window of tacrolimusYes
[52]T32-33AtorvastatinEnhanced effect/
expand time window of hypothermia
Yes
[57]T35EdaravoneEnhanced effectYes
[65]T34CiticolineEnhanced effectYes
[25]T33MinocyclineEnhanced effectYes
[48]P34MinocyclineEnhanced effectNo
[49]P34-35MinocyclineEnhanced effectNo
[69]T35CaffeinolEnhanced effectYes
[72]T35Chlorpromazine and PromethazineEnhanced effectYes
[77]T33MethohexitalEnhanced effectNo
[84]T36XenonEnhanced effectYes
[88]Incomplete35DexmedetomidineEnhanced effectNo
[98]T33t-PA and Normobaric Oxygen (NBO)Enhanced effectYes
[99]
[105]
T
-
33
31
t-PA And normobaric oxygen (NBO)
Hyperbaric oxygenation (HBO2)
Enhanced effect
Enhanced effect
Yes
Yes
[100]T33t-PA and normobaric oxygen (NBO)reduce the side effect of t-PAYes
[115]T33.5-35Granulocyte-Macrophage Colony-Stimulating Factor (G-CSF)Enhanced effectYes
[120]T32Insulin-Like Growth Factors -1(IGF-1)Enhanced effectYes
[121]T30-33Insulin-Like Growth Factors -1(IGF-1)Enhanced effectNo
[128]P33Brain-Derived Neurotrophic Factor (BDNF)Enhanced effectYes
[133]T33Magnesium and TirilazadEnhanced effectYes
[134]T33Magnesium and TirilazadEffectiveYes
[135]T33Magnesium and TirilazadEnhanced effectYes
[59]P32-34MannitolEnhanced effectNo
[60]T33MannitolEnhanced effectNo
[137]T30-31AlbuminEnhanced effectYes
[141]P32Decompressive CraniectomyEnhanced effectYes
[142]P29-31Decompressive CraniectomyEnhanced effectYes
[147]T35PTD-FNKEnhanced effectYes
[150]T33Gene of Bcl-2Expand time window/Enhanced effectYes
Neuronal culture
[78]-22/32Thiopentone Sodium (TPS)Enhanced effectYes
[93]-33DantroleneEnhanced effectYes
Clinical
[31]T33t-PAEnhanced effectNo
[32]T32-34t-PAEnhanced effectNo
[33]T<35.5t-PAFeasible/improve outcomeYes
[34]T34.5t-PAReduce the side effect of tPAYes
[37]Tdecrease 2
in brain
Intra-Arterial RecanalizationFeasible and safeYes
[69]T33-35Caffeinol and T-PAFeasibleYes
[143]P35Decompressive CraniectomyEnhanced effectYes