Longevity Effect of Liuwei Dihuang in Both Caenorhabditis Elegans and Aged Mice
Chen Weidong, Wang Jinzeng, Shi Jiahao, Yang Xu, Yang Ping, Wang Ning, Yang Sai, Xie Tianpei, Yang Hua, Zhang Mengjie, Wang Haiyun, Fei Jian
Table 2 LWDH extended the lifespan of C. elegans at different concentrations.
TreatmentMean life span
± SEM (days)
Percentage changeNumber of animalsP value
Control20.41 ± 1.010-58-
LWDH-0.5 mg/ml23.74 ± 0.855916.30%540.061
LWDH-1 mg/ml26.97 ± 1.03132.09%58< 0.001 (***)
LWDH-1.5 mg/ml28.98 ± 1.32141.98%59< 0.001 (***)
LWDH-2 mg/ml29.84 ± 1.54946.19%51< 0.001 (***)
LWDH-3 mg/ml26.85 ± 2.49631.53%40< 0.001 (***)
LWDH-5 mg/ml7.368 ± 1.157-63.90%57< 0.001 (***)
LWDH-10 mg/ml3.393 ± 0.2096-83.38%56< 0.001 (***)
50 μM Mianserin29.06 ± 0.910742.35%51< 0.001 (***)