Type 2 Myocardial Infarction: A Geriatric Population-based Model of Pathogenesis

Putot Alain, Jeanmichel Melanie, Chague Frederic, Manckoundia Patrick, Cottin Yves, Zeller Marianne

Table 1 Patient characteristics (n (%) or median [IQR]).

Type 1 n=3709 Type 2 n=863 p Risk factors and comorbidities Age, years 67 [56-79] 77 [65-84] <0.001 Female 971 (26) 382 (44) <0.001 BMI, kg/m² 27 [24-30] 26 [23-29] <0.001 Hypertension 2151 (58) 645 (75) <0.001 Hypercholesterolemia 1788 (49) 466 (51) 0.01 Family history of CAD 1095 (30) 209 (24) <0.001 Smoking 1167 (32) 143 (17) <0.001 Diabetes 892 (24) 300 (35) <0.001 Chronic renal failure 171 (5) 112 (13) <0.001 COPD 243 (7) 128 (15) <0.001 Neoplasia 476 (13) 179 (21) <0.001 Cardiovascular history CAD 831 (23) 322 (37) <0.001 Myocardial infarction 319 (9) 135 (16) <0.001 Stroke 252 (7) 119 (14) <0.001 PAD 262 (7) 138 (16) <0.001 Heart failure 135 (4) 113 (13) <0.001 Atrial fibrillation 291 (8) 209 (25) <0.001 Aortic stenosis 111 (3) 128 (15) <0.001 Chronic medication ACEI/ARB 1413 (38) 459 (53) <0.001 Beta blockers 1075 (29) 409 (47) <0.001 Statins 1111 (30) 368 (43) <0.001 Diuretics 986 (27) 461 (53) <0.001 Antiplatelet 386 (10) 177 (20) <0.001 Aspirin 935 (25) 346 (40) <0.001 VKA 232 (6) 171 (20) <0.001 Clinical data at admission Time SO-admission, min 180 [100-480] 150 [60-351] <0.001 Heart rate, b/min 77 [66-90] 85 [71-102] <0.001 SBP, mmHg 140 [121-160] 132 [114-156] <0.001 DBP, mmHg 80 [70-94] 73 [62-85] <0.001 Anterior wall location 1351 (36) 285 (33) 0.06 GRACE risk score 143 [120-170] 171 [138-197] <0.001 Heart failure 812 (22) 396 (46) <0.001 LVEF, % 55 [45-60] 50 [40-60] <0.001 ECG at admission STEMI 1940 (52) 209 (24) <0.001 AF/Flutter 264 (9) 162 (19) <0.001 LBBB 195 (5) 86 (10) <0.001 AVB 91 (2) 22 (1) 0.003 Biological data Hemoglobin, g/100mL 14.4 [13-15.4] 12.7 [10.8-14.2] <0.001 CRP, mg/L 4.6 [2.9-12.0] 13.9 [3.8-60.8] <0.001 Creatinine, µmol/L 80 [70-102] 92 [71-126] <0.001 GFR, mL/min/1.73m2 67 [54-108] 54 [36-80] <0.001 LDL cholesterol, g/L 1.2 [0.9-1.5] 0.9 [0.6-1.2] <0.001 NT-proBNP, pg/mL 578 [150-2334] 3132 [729-10246] <0.001 Troponin Ic peak, µg/L 17 [3-68] 3 [1-14] <0.001 Coronary angiography 3709 (100) 662 (77) <0.001 Normal coronary arteries 10 (0.3) 144 (22) <0.001 MINOCA 54 (1) 245 (37) <0.001 3-vessel or left main disease 1157 (31) 191 (29) 0.2 Revascularization PCI 2980 (80) 204 (24) <0.001 CABG 229 (6) 40 (5) 0.1 Thrombolysis 230 (6) 6 (0.7) <0.001 Hospital outcomes ICU stay, days 4 [3-5] 4 [3-6] 0.05 All cause death 195 (5) 92 (11) <0.001 Cardiovascular death 182 (5) 75 (9) <0.001