The Clinical Efficacy and Safety of Stem Cell Therapy for Diabetes Mellitus: A Systematic Review and Meta-Analysis
Yazhen Zhang, Wenyi Chen, Bing Feng, Hongcui Cao
Table 1 Characteristics of the included studies.
Author and yearCountrySample size (cell therapy/ control)Male (%) (cell therapy/control)Mean age (cell therapy/control) (years)History of DMRegimenRegimens (cell number) doseInjection modeMean follow-up period
Ye 2017 [25]China8/10(T1DM)37.5% /40%18.86 /20.18<6 mBM-HSCNAIV12 m
D'Addio 2014 [18]Poland65(T1DM)63%20.4<12 mBM-HSC5.8 ×l06 /kgIV48 m
Zhang 2012 [26]China9(T1DM)55.6%17.62 yBM-HSC12.31 ×l06 /kgIV12 m
Li 2012 [39]China13(T1DM)69.2%14.1<12 mBM-HSC4 ×l06 /kgIV42 m
Gu 2012 [44]China28(T1DM)50%17.63 mBM-HSCNAIV19.3 m
Snarski 2010 [24]Poland8(T1DM)50%25.82 mBM-HSC4.14×l06 /kgIV7 m
Couri 2009 [28]Brazil23(T1DM)73.9%18.4<2 mBM-HSC10.52×l06 /kgIV29.8 m
Voltarelli 2007 [16]Brazil15(T1DM)73.3%19.2<2 mBM-HSC11 ×l06 /kgIV18.8 m
Carlsson 2014 [27]Sweden9/9(T1DM)88.9% /55.6%24 /27<3 wMSC2.75 ×l06 /kgIV12 m
Hu 2013 [36]China15/14(T1DM)60% /57.1%17.6 /18.2New onsetMSC2.6 ×107/kgIV21 m
Bhansali 2017 [23]India10/10(T2DM)80% /60%50.5 /53.514.5 yMSC1 ×l06 /kgSuperior pancreatico-duodenal artery12 m
Hu 2016 [34]China31/30(T2DM)54.8% /53.3%52.43 /53.218.95 /8.3 yMSC6.1 ×107IV36 m
Skyler 2015 [47]USA45/16(T2DM)62.2% /75%56.7 /58.710.1yMSC1.1×106/kgIV12 w
Guan 2015 [48]China6(T2DM)100%40.542.7 wMSC0.88×106/kgIV33.2 m
Liu 2014 [30]China22(T2DM)68.18%52.98.7 yMSC1×106/kgIV on Day 5+ Splenic artery on Day 1012 m
Jiang 2011 [29]China10(T2DM)70%6611 yMSC1.35 ×106IV6 m
Bhansali 2017 [33]India7(T2DM)85.7%4615 yBM-MNC1.2 ×109Superior pancreatico-duodenal artery6 m
Bhansali 2017 [23]India10/10(T2DM)70% /60%44.5 /53.513.5 yBM-MNC1 ×109Superior pancreatico-duodenal artery12 m
Wu 2014 [32]China20/20(T2DM)60% /55.5%56.4 /54.99.7 yBM-MNC4.01×109Dorsal pancreatic artery12 m
Bhansali 2014 [31]India11/10(T2DM)81.8% /70%51 /5415.8 yBM-MNC2.9 ×108Superior pancreatico-duodenal artery12 m
Hu 2012 [35]China56/62(T2DM)67.8% /58%50.4 /50.28.6 yBM-MNC2.8 ×109Dorsal pancreatic artery33 m
Bhansali 2009 [17]India10(T2DM)80%57.514.6 yBM-MNC3.5 × 108Superior pancreatico-duodenal artery6 m