Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging
Yu-Qing Ni, Xiao Lin, Jun-Kun Zhan, You-Shuo Liu
Table 1 Exosomal non-coding RNAs implicated in ECs functions.
Exosomal non-coding RNAsCargosTargetsECs functionsReference
Exosomal miRNAsmiR-122-5pHGFpro-proliferation, pro-migration[23]
miR-210-3pHGFpro-proliferation, pro-migration[23]
miR-296-5pHGFpro-proliferation, pro-migration[23]
miR-376c-3pHGFpro-proliferation, pro-migration[23]
miR-214ATMpro-proliferation, anti-senescence, pro-angiogenesis[24]
miR-17ANGPT1
STAT3
pro-proliferation, pro-migration,
anti-inflammation
[25] [35]
miR-19ANGPT1pro-proliferation, pro-migration[25]
miR-20aANGPT1pro-proliferation, pro-migration[25]
miR-30cANGPT1pro-proliferation, pro-migration[25]
miR-126ANGPT1pro-proliferation, pro-migration[25]
miR-92aSOCS5anti- proliferation, pro-inflammation[26] [30]
miR-21RhoBanti- proliferation, pro-inflammation[27] [31]
miR-24Sp1anti- proliferation[28]
miR-15aVEGF, NF-kBpro-inflammation[32, 33]
miR-27aVEGF, EGFRpro-inflammation[32, 33]
miR-34aBCL2, SIRT1pro-inflammation[32, 33]
miR-223ICAM-1anti-inflammation[34]
miR-125aDLL4pro-angiogenesis[36]
miR-181b-5pTRPM7pro-angiogenesis[37]
miR-106b-5pANG2anti- angiogenesis[38]
miR-320IGF-1, Hsp20, Ets2anti- angiogenesis[39]
Exosomal lncRNAsHOTTIPcyclin D1, PCNApro-proliferation, pro-migration[48]
POU3F3bFGF, VEGFpro-proliferation, pro-migration,
pro-angiogenesis
[49]
MALAT1IL-6, TNF-α, SAA3anti- proliferation, pro-migration,
pro-inflammation
[50]
[59, 60]
HOTAIRVEGFpro-angiogenesis[53]
H19Unknownpro-angiogenesis[54]
CCAT2TGFβ, Bcl-2pro-angiogenesis, anti-apoptosis[55]
Meg3Unknownanti- angiogenesis[57]
GAS5P53, Caspase 3, Caspase 7pro-apoptosis[58]