Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging

Yu-Qing Ni, Xiao Lin, Jun-Kun Zhan, You-Shuo Liu

Table 3 Roles of exosomal miRNAs in vascular aging related diseases.

Cargo Disease Functions Heart Diseases miR-221/222 CAD Promote the progression of CAD [103] miR-208a CAD Promote the progression of CAD [104] miR-126 CAD Inhibit the progression of CAD [105] miR-17-92 CAD Inhibit the progression of CAD [106] miR-22 AMI Protect against CMCs apoptosis [108] miR-133 AMI Promote the progression of AMI [109] miR-21 AMI, HF Promote CMCs loss [110, 113] miR-24 HF Promote the progression of HF [114] miR-214 HF Promote the progression of HF [115] Hypertension miR-211 EH Activate the axis of RAAS [119] miR-615 EH Activate the axis of RAAS [119] miR-155 EH Regulate the progression of VC [99] Cerebrovascular Diseases miR-126 AIS Inhibit microglial activation and inflammatory response [122] miR-30d-5p AIS Inhibit autophagy-mediated microglial polarization to M1 [123] miR-181b-5p AIS promoted BMEC angiogenesis [37] miR-146a VCID Inhibit inflammatory effects on damaged astrocytes [124] Kidney Diseases miR-200b CKD Regulate the progression of renal fibrosis [126] miR-16 CKD Regulate the progression of CKD [127] PAD miR-92a Hind Limb Ischemia Inhibit functional recovery [129]