Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in C. elegans

Andreas Jahn, Bo Scherer, Gerhard Fritz, Sebastian Honnen

Table 1 Mean aging pigment accumulation in populations with different genetic backgrounds with and without statin treatment.

Genetic background (allele) [start of treatment] group Day 12: Mean aging pigments ± SEM (RFU) Number of individuals (N) % change vs. control p-value vs. control Wt [adult +1]  control 2454±223 52 20.3 0.152  25 µM lovastatin 1955±108 42 22.93 0.113  50 µM lovastatin 1891±88 45 40.11 0.038*  100 µM lovastatin 1469±231 42 Wt [adult +1]  empty Vector 4314±5 31 41.89  1:8 hmgr-1 RNAi 2507±166 30 43.76  1:16 hmgr-1 RNAi 2426±136 30 47.26  1:24 hmgr-1 RNAi 2275±217 30 45.07  1:32 hmgr-1 RNAi 2370±70 30 Wt [adult +1]  empty Vector 2339±305 30 11.42 0.35  1:64 hmgr-1 RNAi 1998±187 31 9.2 0.144  1:128hmgr-1 RNAi 2094±210 30 daf-16(mu86) [adult +1]  control 1146±201 20 11.41 0.038*  100 µM lovastatin 1276±165 21 daf-2(e1370) [adult +1]  control 2744±66 30 3.39 0.657  100 µM lovastatin 2837±139 30 jnk-1(gk7) [adult +1]  control 1867±282 31 7 0.716  100 µM lovastatin 1736±175 31