Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in C. elegans

Andreas Jahn, Bo Scherer, Gerhard Fritz, Sebastian Honnen

Table 2 Mean or post-reproductive lifespan of populations with different genetic backgrounds with and without statin treatment.

Genetic background(allele) [start of treatment] group Mean lifespan± SEM (days) Number of individuals (N) % Change vs. control p-value vs. control Wt [adult +1]  control 21.76±0.68 128  25 μM lovastatin 24.58±0.64 132 12.96 0.004*  50 μM lovastatin 24.62±0.72 130 13.14 0.001*  100 μM lovastatin 27.10±0.76 123 24.54 <0.001* Wt [adult +8]  control 12.80±0.49 96  25 μM lovastatin 15.22±0.48 96 18.91 <0.001*  50 μM lovastatin 15.94±0.50 96 24.53 <0.001*  100 μM lovastatin 16.63±0.51 86 29.92 <0.001* Wt [adult+1]  control 16.88±0.61 102  25 μM simvastatin 17.30±0.56 113 2.5 0.89  50 μM simvastatin 19.11±0.66 107 13.2 0.001*  100 μM simvastatin 19.05±0.78 106 12.9 <0.001* daf-16(mu86) [adult +1]  control 17.11±0.33 213  100 μM lovastatin 17.50±0.33 213 2.27 0.320 daf-2(e1370) [adult +1]  control 25.13±0.73 214  100 μM lovastatin 27.84±0.92 199 10.78 0.002* jnk-1(gk7) [adult +1]  control 22.49±0.44 186  100 μM lovastatin 22.10±0.49 187 1.73 0.856