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Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated Aging
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Xiaojie Zhao, Yan Fan, Philip H. Vann, Jessica M. Wong, Nathalie Sumien, Johnny J. He
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Table 2 Summary of comparisons between different mice/sex and different brain regions. |
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| | Male iTat vs Wt | Female iTat vs Wt | Total Male vs Female |
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Behavior | MWZ | ↓↓ | - | ↑ | OPT | - | - | - | BW | ↓↓ | ↓↓↓↓ | ↓ | |
| CORT | GFAP | ↑ | ↑ | - | SYP | - | ↑ | - | PSD95 | - | ↑ | - | DNMT3B | - | ↑ | - | 5-MC | ↓ | - | ↑ | |
| CERE | GFAP | - | - | ↓ | SYP | ↓ | - | - | PSD95 | - | - | ↓ | DNMT3B | ↓ | - | - | 5-MC | - | ↓ | - | |
| HIP | GFAP | - | - | ↑ | SYP | - | - | - | PSD95 | - | - | - | DNMT3B | - | - | - | |
| CPU | GFAP | ↑ | ↑ | - | SYP | - | - | - | PSD95 | - | - | - | DNMT3B | - | - | - |
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