Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

Leng Zikuan, Zhu Rongjia, Hou Wei, Feng Yingmei, Yang Yanlei, Han Qin, Shan Guangliang, Meng Fanyan, Du Dongshu, Wang Shihua, Fan Junfen, Wang Wenjing, Deng Luchan, Shi Hongbo, Li Hongjun, Hu Zhongjie, Zhang Fengchun, Gao Jinming, Liu Hongjian, Li Xiaoxia, Zhao Yangyang, Yin Kan, He Xijing, Gao Zhengchao, Wang Yibin, Yang Bo, Jin Ronghua, Stambler Ilia, Lim Lee Wei, Su Huanxing, Moskalev Alexey, Cano Antonio, Chakrabarti Sasanka, Min Kyung-Jin, Ellison-Hughes Georgina, Caruso Calogero, Jin Kunlin, Zhao Robert Chunhua

Table 4 The laboratory results of the critically severe patient. Red: the value was above the normal. Blue: the value was below the normal. NA: Not Available.

Reference range Jan 24 Jan 30 Jan 31 Feb 1 Feb 2 Feb 4 Feb 6 Feb 10 Feb 13 C-reactive protein (ng/mL) < 3.00 2.20 105.50 NA 191.00 83.40 13.60 22.70 18.30 10.10 Absolute lymphocyte count (× 109/L) 1.10-3.20 0.94 0.60 0.35 0.23 0.35 0.58 0.87 0.73 0.93 White-cell count (× 109/L) 3.50-9.50 4.91 6.35 7.90 7.08 12.16 12.57 11.26 10.65 8.90 Absolute neutrophil count (× 109/L) 1.80-6.30 3.43 5.43 7.28 6.63 11.33 11.10 9.43 9.18 7.08 Absolute monocyte count (× 109/L) 0.10-0.60 0.38 0.25 0.17 0.13 0.35 0.61 0.52 0.48 0.56 Red-cell count (× 1012 /L) 4.30-5.80 4.69 4.68 4.66 4.78 4.73 4.75 5.16 4.69 4.53 Hemoglobin (g/L) 130.00-175.00 145.00 147.00 145.00 146.00 142.00 145.00 155.00 145.00 137.00 Platelet count (× 109/L) 125.00-350.00 153.00 148.00 169.00 230.00 271.00 268.00 279.00 332.00 279.00 Absolute eosinophil count (× 109/L) 0.02-0.52 0.02 0.02 0.02 0.02 0.02 0.05 0.15 0.14 0.14 Absolute basophilic count (× 109/L) 0.00-0.06 0.02 0.01 0.02 0.02 0.02 0.06 0.10 0.03 0.04 Total bilirubin (μmol/L) 5.00-21.00 7.00 23.00 21.70 19.80 14.20 15.80 16.50 12.50 8.70 Albumin (g/L) 40.00-55.00 41.70 32.30 29.70 29.90 31.60 33.00 32.20 30.10 29.10 Aspartate amino transferase (U/L) 15.00-40.00 14.00 33.00 48.00 57.00 39.00 34.00 23.00 25.00 19.00 Fibrinogen (g/L) 2.00-4.00 2.44 4.24 NA NA 4.73 NA 3.12 3.84 3.73 Procalcitonin (ng/mL) < 0.10 0.11 0.12 NA NA NA 0.10 0.18 0.15 < 0.10 Creatine kinase isoenzymes (ng/mL) < 3.60 0.90 0.12 NA 5.67 4.24 NA 0.88 0.90 0.61 Creatine kinase (U/L) 50.00-310.00 168.00 231.00 NA 513.00 316.00 NA 47.00 83.00 40.00 Glomerular filtration rate (ml/min) > 90.00 81.30 68.00 89.60 99.00 104.00 92.50 108.10 97.10 94.10 Potassium (mmol/L) 3.50-5.30 3.61 2.74 3.00 3.42 3.47 4.18 4.36 4.69 4.61 Sodium (mmol/L) 137.00-147.00 138.50 132.60 129.50 132.80 136.90 135.80 133.80 134.10 137.70 Myoglobin (ng/mL) 16.00-96.00 53.00 80.00 NA 138.00 77.00 NA 62.00 60.00 43.00 Troponin (ng/mL) < 0.056 0.10 0.07 NA 0.05 0.05 NA 0.02 0.04 0.04