Role of Mitophagy in Cardiovascular Disease

Yang Yibo, Li Tianyi, Li Zhibo, Liu Ning, Yan Youyou, Liu Bin

Table1 Therapeutic application of mitophagy.

Diseases Representatives Mechanisms Effects References MicroRNAs I/R MiR-410 Mitophagy- damage [165] I/R MiR-137 BNIP3/FUNDC1- - [166] Cardiac Lipotoxicity, DCM MiR-133a Nix- protection [167] Clinical drugs and chemical reagents I/R Melatonin PINK1/Parkin- protection [168] DCM Melatonin PINK1/Parkin+ protection [169] AS Melatonin PINK1/Parkin+ protection [170] I/R Simvastatin Parkin/P62+ protection [171] I/R Liraglutide Parkin+ protection [172] I/R Zine PINK1+ protection [173] I/R Sevoflurane postconditioning Parkin- protection [174] I/R TEMPOL preconditioning PINK1/Parkin+ protection [175] HF Curcumin BNIP3- protection [176] Cardiotoxicity Ellagic acid BNIP3- protection [177] Stroke Tunicamycin and thapsigargin Mitophagy+ protection [178] Stroke Peroxynitrite PINK1/Parkin+ damage [179] Stroke Naringin Parkin- protection [180] Signal pathways AS NR4A1/CaMKII activation Parkin+ damage [145] Stroke MAPK-ERK-CREB blockade Mfn2- damage [181] I/R Rab5 endosomal pathway activation Parkin+ protection [182]. I/R P53/TIGAR activation BNIP3- damage [183] HF JNK/FOXO3a activation BNIP3+ damage [184]. Activators/inhibitors, genes knock in/out I/R STAT1 activation Mitophagy- damage [185] AS PINK1/Parkin knockout PINK1/Parkin- damage [146, 147] I/R GPER activation PINK1/Parkin- protection [93] I/R ALDH2 activation PINK1/Parkin- protection [186] DCM Sirt3 overexpression Parkin+ protection [187] DCM Mst1 knockout Parkin+ protection [188] HF BAG3 knockdown Parkin- damage [189] AS F13A PINK1/Parkin- protection [190] HF CsA PINK1/Parkin- protection [191] HF Akt2 knockout BNIP3/PINK1/Parkin+ protection [192] Stroke Nix knockout Nix- damage [161] I/R DUSP1 activation BNIP3- protection [98] HF SWI/SNF deletion BNIP3+ damage [193] I/R FUNDC1 knockout FUNDC1- damage [96] Environmental stimuli I/R Mild hypothermia Parkin- protection [194] I/R Hypoxic preconditioning FUNDC1+ protection [96] Myocardial inflammatory Acute exercise BNIP3+ protection [80] I/R Exercise preconditioning Parkin+ protection [195] Stroke Acidic postconditioning Mitophagy+ protection [196] Stroke Remote ischemic post conditioning Parkin+ protection [197]