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Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering
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Zhang Shuyuan, Li Rongxia, Yang Yunyun, Chen Yu, Yang Shujun, Li Jian, Wu Cunjin, Kong Tao, Liu Tianlong, Cai Jun, Fu Li, Zhao Yanan, Hui Rutai, Zhang Weili
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| Table 1 Baseline characteristics of patients between the shorten and lengthen groups categorized by annual telomere attrition rate during 2014-2016. |
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| Annual telomere attrition rate | |
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| Characteristics | Total (n=1,108) | Shorten group (n=386) | Lengthen group (n=722) | P value† | | Age, years | 61.7 ± 9.7 | 62.3 ± 9.6 | 61.4 ± 9.8 | 0.13 | | Men, No. (%) | 430 (38.8%) | 155 (40.2%) | 275 (38.1%) | 0.52 | | BMI, kg/m2 | 26.2 ± 3.1 | 26.3 ± 3.2 | 26.2 ± 3.1 | 0.85 | | Waist-to-hip ratio | 0.90 ± 0.05 | 0.90 ± 0.05 | 0.90 ± 0.05 | 0.09 | | Systolic BP, mm Hg | 160 ± 21 | 159 ± 21 | 160 ± 21 | 0.27 | | Diastolic BP, mm Hg | 89 ± 12 | 89 ± 11 | 89 ± 12 | 0.92 | | Fasting serum glucose, mmol/L | 6.2 ± 1.7 | 6.1 ± 1.5 | 6.3 ± 1.8 | 0.10 | | Lipids, mmol/L | | | | | | Total cholesterol | 5.7 ± 1.1 | 5.6 ± 1.1 | 5.7 ± 1.1 | 0.41 | | Triglycerides | 1.6 (1.1-2.3) | 1.6 (1.1-2.2) | 1.6 (1.1-2.4) | 0.23 | | HDL-C | 1.3 ± 0.3 | 1.3 ± 0.3 | 1.3 ± 0.3 | 0.40 | | LDL-C | 3.6 ± 0.9 | 3.6 ± 0.9 | 3.6 ± 0.9 | 0.48 | | Smoking status, % | | | | | | Never | 73.8 | 73.1 | 74.1 | 0.41 | | Former | 7.4 | 8.8 | 6.6 | | | Current | 18.8 | 18.1 | 19.1 | | | Alcohol intake, % | | | | | | Never | 77.0 | 77.7 | 76.6 | 0.58 | | Former | 5.1 | 5.7 | 4.7 | | | Current | 18.0 | 16.6 | 18.7 | | | Medical history, % | | | | | | Diabetes mellitus | 23.8 | 21.8 | 24.9 | 0.27 | | Stroke | 21.1 | 23.1 | 20.1 | 0.25 | | Coronary heart disease | 29.7 | 30.6 | 29.2 | 0.68 | | Antihypertensive drugs, No. (%) | | | | | | Calcium channel blocker | 744 (67.1) | 251 (65.0) | 493 (68.3) | 0.28 | | Angiotensin receptor blocker | 590 (53.2) | 192 (49.7) | 398 (55.1) | 0.09 | | ACE inhibitor | 87 (7.9) | 35 (9.1) | 52 (7.2) | 0.29 | | Beta-blocker | 24 (2.2) | 11 (2.8) | 13 (1.8) | 0.28 | | Diuretics | 300 (27.1) | 104 (26.9) | 196 (27.1) | 0.99 | | Leukocytes telomere length, T/S ratio | | | | | | At baseline | 1.4 (1.0-1.8) | 1.8 (1.4-2.3) | 1.2 (0.9-1.6) | <0.001 | | At follow-up | 1.9 (1.3-2.5) | 1.1 (0.8-1.5) | 2.2 (1.7-3.0) | <0.001 | | Telomere length, base pairs (Kb)* | | | | | | At baseline | 6.6 (5.7-7.7) | 7.5 (6.5-8.9) | 6.3 (5.5-7.2) | <0.001 | | At follow-up | 7.8 (6.3-9.4) | 6.0 (5.2-6.9) | 8.6 (7.4-10.4) | <0.001 |
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