Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering

Zhang Shuyuan, Li Rongxia, Yang Yunyun, Chen Yu, Yang Shujun, Li Jian, Wu Cunjin, Kong Tao, Liu Tianlong, Cai Jun, Fu Li, Zhao Yanan, Hui Rutai, Zhang Weili

Table 2 Association of annual telomere attrition rate with BP change during 2014-2016.

Annual telomere Mode I* Model II† Change in BP attrition rate β SE P value β SE P value Total (n=1,108) ΔSBP Shorten (n=386) Ref. Ref. Lengthen (n=722) -3.20 1.35 0.02 -3.28 1.37 0.02 ΔDBP Shorten (n=386) Ref. Ref. Lengthen (n=722) -0.58 0.73 0.43 -0.78 0.74 0.29 ΔPP Shorten (n=386) Ref. Ref. Lengthen (n=722) -2.74 1.10 0.01 -2.53 1.11 0.02 Men (n=430) ΔSBP Shorten (n=155) Ref. Ref. Lengthen (n=275) -2.19 2.14 0.31 -2.68 2.16 0.15 ΔDBP Shorten (n=155) Ref. Ref. Lengthen (n=275) -0.78 1.20 0.52 -1.05 1.19 0.38 ΔPP Shorten (n=155) Ref. Ref. Lengthen (n=275) -1.48 1.73 0.39 -1.34 1.72 0.44 Women (n=678) ΔSBP Shorten (n=231) Ref. Ref. Lengthen (n=447) -3.91 1.73 0.02 -3.56 1.76 0.04 ΔDBP Shorten (n=231) Ref. Ref. Lengthen (n=447) -0.71 0.92 0.45 -0.81 0.94 0.39 ΔPP Shorten (n=231) Ref. Ref. Lengthen (n=447) -3.42 1.42 0.02 -3.25 1.44 0.03 ≤60 years (n=506) ΔSBP Shorten (n=169) Ref. Ref. Lengthen (n=337) -6.41 1.90 0.001 -6.82 1.91 <0.001 ΔDBP Shorten (n=169) Ref. Ref. Lengthen (n=337) -2.37 1.10 0.03 -2.49 1.11 0.03 ΔPP Shorten (n=169) Ref. Ref. Lengthen (n=337) -3.97 1.46 0.007 -4.23 1.47 0.004 >60 years (n=602) ΔSBP Shorten (n=217) Ref. Ref. Lengthen (n=385) -1.53 2.08 0.46 -1.42 2.13 0.51 ΔDBP Shorten (n=217) Ref. Ref. Lengthen (n=385) 0.76 0.97 0.43 0.41 1.0 0.68 ΔPP Shorten (n=217) Ref. Ref. Lengthen (n=385) -1.46 1.58 0.35 -1.74 1.77 0.33