Longitudinal Association of Telomere Attrition with the Effects of Antihypertensive Treatment and Blood Pressure Lowering
Zhang Shuyuan, Li Rongxia, Yang Yunyun, Chen Yu, Yang Shujun, Li Jian, Wu Cunjin, Kong Tao, Liu Tianlong, Cai Jun, Fu Li, Zhao Yanan, Hui Rutai, Zhang Weili
Table 3 Association of telomere attrition with effects of antihypertensive treatment.
Change in bloodAnnual telomereModel I*Model II†
pressureattrition rateβSEP valueβSEP value
CCB therapy (n=744)
ΔSBPShorten (n=251)Ref.Ref.
Lengthen (n=493)-4.721.950.02-4.731.980.02
ΔDBPShorten (n=251)Ref.Ref.
Lengthen (n=493)-1.560.980.11-1.620.990.10
ΔPPShorten (n=251)Ref.Ref.
Lengthen (n=493)-3.591.510.02-3.531.530.02
ARB therapy (n=590)
ΔSBPShorten (n=192)Ref.Ref.
Lengthen (n=398)-5.082.130.02-4.752.160.03
ΔDBPShorten (n=192)Ref.Ref.
Lengthen (n=398)-1.191.080.27-1.311.090.23
ΔPPShorten (n=192)Ref.Ref.
Lengthen (n=398)-4.201.680.01-3.561.700.04
Diuretic therapy (n=300)
ΔSBPShorten (n=104)Ref.Ref.
Lengthen (n=196)-4.192.990.16-2.863.060.35
ΔDBPShorten (n=104)Ref.Ref.
Lengthen (n=196)-1.391.530.36-1.371.530.37
ΔPPShorten (n=104)Ref.Ref.
Lengthen (n=196)-2.102.610.42-0.842.650.75