COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile

Fulzele Sadanand, Sahay Bikash, Yusufu Ibrahim, Lee Tae Jin, Sharma Ashok, Kolhe Ravindra, Isales Carlos M

Table 3 List of human miRNAs with higher target score (above 94), the number of binding sites, and miRNAs seed binding site on COVID-19 isolates.

miRNAs Target Score Number of Sites and Seed locations of miRNAs and COVID-19 genome binding sites miR-15b-5p miR-15a-5p 99 16 SITES (3163, 5384, 8458, 8614, 13090, 14562, 14781, 19857, 24094, 24634, 25683, 26723, 28921, 28935, 28938, 29023) (Note: miR-15b-5p, and miR-15a-5p have same target site) miR-548c-5p 97 15 SITES (2733, 4025, 4531, 6783, 7774, 9508, 10962, 11641, 11672, 12950, 13644, 20196, 21886, 23026, 25807) miR-548d-3p 94 13 SITES (6960, 7245, 7272, 8927, 11540, 13459, 15517, 15814, 18367, 21100, 22217, 22583, 26653) miR-409-3p 96 12 SITES (4990, 8386, 11785, 12403, 12525, 17285, 19760, 19803, 20759, 20829, 28767, 29694) miR-30b-5p 95 14 SITES (3451, 4974, 7939, 9354, 10426, 11657, 16863, 19567, 19710, 20069, 20360, 26729, 27955, 28140) miR-505-3p 95 11 SITES (152, 8488, 10609, 10792, 14208, 15648, 17580, 18123, 18156, 18612, 18906)