COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile

Fulzele Sadanand, Sahay Bikash, Yusufu Ibrahim, Lee Tae Jin, Sharma Ashok, Kolhe Ravindra, Isales Carlos M

Table 4 Summary of important findings on human miRNAs targeting SARS and COVID-19 genome.

Serial. No Important findings on human miRNAs targeting Coronavirus 1 848 miRNAs are common in SARS 2 873 miRNAs are common inCOVID-19 3 558 miRNAs are common between SARS and COVID-19 4 315 miRNAs are unique to COVID-19 5 290 miRNAs are unique to SARS 6 10 COVID-19 isolates have some unique miR targets 7 MT050493.1 (India): 1 unique miRNA (hsa-miR-449c-3p) 8 MT007544.1 (Australia): 2 unique miRNAs (hsa-miR-4538, hsa-miR-4453) 9 EPI_ISL_402121 (Wuhan/China): 1 unique miRNA (hsa-miR-5590-5p) 10 EPI_ISL_402123 (Wuhan/China): 1 unique miRNA (hsa-miR-106a-3p) 11 EPI_ISL_420799 (South Korea): 1 unique miRNA (hsa-miR-4641) 12 EPI_ISL_427391 (Turkey): 1 unique miRNA (hsa-miR-496) 13 EPI_ISL_429223 (Switzerland): 1 unique miRNA (hsa-miR-146b-3p) 14 EPI_ISL_403931 (Wuhan): 4 unique miRNAs (hsa-miR-4474-3p, hsa-miR-6762-3p, hsa-miR-10401-5p, hsa-miR-4304) 15 EPI_ISL_413214 (Australia): 4 unique miRNAs (hsa-miR-5088-5p, hsa-miR-9900, hsa-miR-3677-5p, hsa-miR-892c-5p) 16 EPI_ISL_422601 (Netherland): 6 unique miRNAs (hsa-miR-4666a-3p, hsa-miR-98-3p, hsa-let-7b-3p, hsa-let-7a-3p, hsa-miR-381-3p, hsa-miR-300)