MEG3
-expressed in the nucleus and cytoplasm | -upregulated in the hippocampus of old mice;
-downregulated in old induced striatal medium-sized spiny neurons (MSSNs); - PTEN/PI3K/AKT signaling cascade | -cognitive decline
-downregulated in HD brain tissue - synaptic plasticity in neurons | [30], [92] |
| SORL1-AS | - upregulated in AD disease brain affecting Aβ formation | -AD;
-Protein aggregation; -cognitive impairment | [30], [93] |
Six3OS
-spatiotemporal expression | - Regulation of Six3 targets through interactions with Eya proteins and the chromatin-modifying protein Ezh2; | - adult mouse neurogenesis | [94] |
| 17A | -upregulated in frontal and temporal cortices
-increases Aβ secretion | -AD;
-Abolish GABA B2 intracellular signaling | [95] |
| MALAT-1 | - upregulated in human aged SVZ;
-upregulated in the hippocampus of old mice; - scaffold for proteins and RNAs | -cognitive decline;
-neurodegeneration; -PD | [30], [96], [97] |
| UCHL1-AS | -downregulated in murine dopaminergic cells;
- regulated by a transcription factor Nurr1 required for dopamine cells differentiation | - Neurodegeneration;
-PD | [50] |
| ANRIL | -altered expression in all tissues | -AD;
- Neurodegeneration; | [98] |
| HOTAIR | - high expression of HOTAIR promotes PD | -PD | [99] |
| BACE1-AS | - Increases BACE1 mRNA stability and Aβ42 formation | - up-regulated in AD brains | [100], [101] |