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He Feng, Quan Yibo, Lei Ming, Liu Riguang, Qin Shuguang, Zeng Jun, Zhao Ziwen, Yu Na, Yang Liuping, Cao Jie
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| Characteristic | Total (n=288) | non-CVD
(n=203) | CVD
(n=85) | p value |
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| Demographics | | | | | | Age, median (IOR), years | 48.5 (34.3, 62.0) | 43.0 (32.0, 57.0) | 62.0 (53.3, 67.0) | <0.0001 | | Male, n (%) | 131 (45.5) | 85 (41.9) | 118 (58.1) | 0.057 | | Comorbidities | | | | | | Hypertension | 84 (29.2) | 1 (0.5) | 83 (97.6) | <0.0001 | | Diabetes | 24 (8.3) | 8 (3.9) | 16 (18.8) | <0.0001 | | Chronic kidney disease | 8 (2.8) | 3 (1.5) | 5 (5.9) | 0.038 | | COPD | 5 (1.7) | 1 (0.5) | 4 (4.8) | 0.012 | | Cerebrovascular disease | 8 (2.8) | 0 (0.0) | 8 (9.4) | <0.0001 | | Chronic liver disease | 10 (3.5) | 6 (3.0) | 4 (4.7) | 0.459 | | Malignancy | 6 (2.1) | 4 (2.0) | 2 (2.4) | 0.836 | | Signs and symptoms | | | | | | Fever | 201 (69.8) | 146 (71.9) | 55 (64.7) | 0.224 | | Chill | 55 (19.1) | 44 (21.7) | 11 (12.9) | 0.085 | | Cough | 163 (56.6) | 110 (54.2) | 53 (62.4) | 0.202 | | Rhinorrhea | 18 (6.3) | 11 (5.4) | 7 (8.2) | 0.368 | | Sore throat | 67 (23.3) | 44 (21.7) | 23 (27.1) | 0.324 | | Fatigue | 43 (14.9) | 34 (16.7) | 9 (10.6) | 0.181 | | Myalgia or arthralgia | 35 (12.2) | 25 (12.3) | 10 (11.8) | 0.896 | | Headache | 26 (9.0) | 21 (10.3) | 5 (5.9) | 0.228 | | Nausea | 28 (9.7) | 22 (10.8) | 6 (7.1) | 0.324 | | Diarrhea | 11 (3.8) | 10 (4.9) | 1 (1.2) | 0.13 | Respiratory rate
≥24 breaths per min | 19 (6.6) | 8 (3.9) | 11 (12.9) | 0.005 | | Oxygen support | | | | | | None | 88 (30.6) | 65 (32.0) | 23 (27.1) | 0.405 | | Normal-flux | 184 (63.9) | 131 (64.5) | 53 (62.4) | 0.725 | | High-fux | 16 (5.6) | 7 (3.4) | 9 (10.6) | 0.016 | Non-invasive mechanical
ventilation | 32 (11.1) | 15 (7.4) | 17 (20) | 0.002 | | Unilateral pneumonia | 241 (83.7) | 165 (81.3) | 76 (89.4) | 0.089 | | Bilateral pneumonia | 31 (10.8) | 25 (12.4) | 6 (7.1) | 0.185 | | Laboratory variables | | | | | | White blood cell, × 109/L | 5.20 (4.14, 6.44) | 5.01(4.03, 6.22) | 5.64 (4.42, 7.18) | 0.271 | White blood cell count, × 109/L
(No. (%)) | | | | 0.109 | | ≤4 | 62 (21.5) | 49 (24.1) | 13 (15.3) | | | 4-10 | 216 (75.0) | 149 (73.4) | 67 (78.8) | | | >10 | 10 (3.5) | 5 (2.5) | 5 (5.9) | | | Lymphocyte count, × 109/L | 1.42 (1.04, 1.96) | 1.45 (1.06, 2) | 1.31 (0.9, 1.84) | 0.373 | Lymphocyte count, × 109/L
(No. (%)) | | | | 0.751 | | <1.1 | 91 (31.6) | 63 (31.0) | 28 (32.9) | | | Platelet count, × 109/L | 194.5 (158, 247) | 196 (160, 248) | 190 (153, 240.5) | 0.762 | | Hemoglobin, g/L | 135.5 (123, 147) | 135 (123, 146) | 136 (121.5, 147.5) | 0.782 | | Procalcitonin, ng/mL | 0.13 (0.04, 32.6) | 0.09 (0.03, 32.6) | 0.30 (0.05, 34.9) | 0.314 | | C-reactive protein, mg/L | 9 (8, 22.7) | 9 (8, 18.04) | 13.18 (8, 37.5) | 0.004 | C-reactive protein, mg/L
(No. (%)) | | | | 0.001 | | ≤10 | 175 (60.8) | 136 (67) | 39 (45.9) | | | >10 | 113 (39.2) | 67 (33) | 46 (54.1) | | | Troponin I, μg/L (No. (%)) | | | | 0.002 | | ≤0.03 | 168 (88.4) | 116 (93.5) | 52 (78.8) | | | >0.03 | 22 (11.6) | 8 (6.5) | 14 (21.2) | | | BNP, μg/L | 35 (13, 117.5) | 18.5 (9, 74.5) | 45 (22, 179) | 0.177 | | Creatine kinase, U/L | 52 (36, 80) | 54 (38, 80) | 48.5 (28.75, 82.5) | 0.385 | | Creatinine, μmol/L | 61.8 (50.2, 76.58) | 58.8 (48.1, 74.9) | 66.9 (52.1, 78) | 0.001 | | ATL, U/L | 22.45 (14.3, 34.5) | 22.4 (14, 34.4) | 22.5 (15.9, 34.9) | 0.317 | | AST, U/L | 18.35 (14.9, 25.63) | 17.7 (13.7, 24.5) | 19.4 (16.4, 27.4) | 0.105 | | Complications | | | | | | Acute cardiac injury | 22 (11.6) | 8 (6.5) | 14 (21.2) | 0.020 | | ARDS | 3 (1.0) | 1 (0.5) | 2 (2.4) | 0.156 | | Acute kidney injury | 5 (1.7) | 2 (1.0) | 3 (3.5) | 0.132 | Clinical Types a
(Severe/Critically severe) | 30 (10.4) | 15 (7.4) | 15 (17.6) | 0.009 | | ICU Admission | 27 (9.4) | 12 (5.9) | 15 (17.6) | 0.002 |
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