Clinical features and risk factors for ICU admission in COVID-19 patients with cardiovascular diseases

He Feng, Quan Yibo, Lei Ming, Liu Riguang, Qin Shuguang, Zeng Jun, Zhao Ziwen, Yu Na, Yang Liuping, Cao Jie

Table 2 Risk factors of ICU admission for COVID-19 patients with CVD.

Univariable OR (95% CI) p value Multivariable OR (95% CI) p value Age, years 1.09 (1.02-1.15) 0.010 1.08 (1.02-1.17) 0.018 Female sex (vs. male) 0.24 (0.06-0.91) 0.036 0.18 (0.29-1.06) 0.058 Diabetes 1.76 (0.48-6.46) 0.396 .. .. Chronic kidney disease 3.44 (0.52-22.64) 0.199 .. .. COPD 1.72 (0.17-17.83) 0.650 .. .. Cerebrovascular disease 1.64 (0.30-9.05) 0.57 .. .. Fever 1.63 (0.47-5.63) 0.444 .. .. Cough 2.83 (0.73-10.93) 0.132 .. .. Respiratory rate ≥24 breaths per min 37.77 (5.52-258.28) <0.0001 25.52 (5.48-118.87) <0.0001 White blood cell count, ×109/L ≤4 0 0.999 .. .. 4-10 1(ref) .. .. .. >10 2.77 (0.42-18.31) 0.291 .. .. Lymphocyte count, ×109/L <1.1 5.78 (1.74-19.18) 0.004 0.47 (0.15-1.52) 0.210 ≥1.1 1(ref) .. 1(ref) .. Procalcitonin, ng/mL <0.05 1(ref) .. 1(ref) .. 0.05-10 4.07 (0.78-21.27) 0.096 4.13 (0.42-40.77) 0.225 >10 1.31 (0.22-7.87) 0.768 0.48 (0.03-7.44) 0.602 C-reactive protein, mg/L <10 1(ref) .. 1(ref) .. ≥10 24.57 (5.69-106.13) <0.0001 8.12 (1.63-40.49) 0.011 Troponin I, ug/L ≤0.03 1(ref) .. 1(ref) .. >0.03 14.72 (5.03-43.13) <0.0001 9.14 (2.66-31.43) <0.0001 BNP, 100 μg/L ≤100 1(ref) .. .. .. >100 60 (5.47-658.76) 0.001 .. .. Creatinine, μmol/L ≤106 1(ref) .. 1(ref) .. >106 5.31 (1.25-22.60) 0.024 2.00 (0.18-22.08) 0.572