Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysis

Wu Ting, Zuo Zhihong, Kang Shuntong, Jiang Liping, Luo Xuan, Xia Zanxian, Liu Jing, Xiao Xiaojuan, Ye Mao, Deng Meichun

Table 2 Comparison of impacts of organ function on severity of COVID-19, MERS and SARS.

OR/WMD, 95%CI COVID-19 SARS MERS Cardiac function Hypertension OR = 2.40; 95% CI, 2.08-2.78 OR138 = 2.6; 95% CI, 2.2-3.5 CVD OR = 3.54; 95% CI, 2.68-4.68 OR = 7.42; 95% CI, 4.34-12.69 OR138 = 3.5; 95% CI, 3.1-4.8 LDH U/L WMD = 140.27; 95% CI, 102.18-178.36 WMD = 214.14; 95% CI, 31.09-217.19 CK, U/L WMD = 34.01; 95% CI, 9.46 -58.59 WMD = 149.91; 95% CI, 94.03-205.79 Renal function CKD OR = 1.84; 95% CI, 1.47-2.30 OR = 7.82; 95% CI, 3.52-17.38 OR138= 2.2; 95% CI, 1.7-4.9 Creatinine, μmol/L WMD = 10.40; 95% CI, 8.07 - 12.72 WMD = 10.31; 95% CI, 6.76 - 13.85 WMD = 109.92; 95% CI, 21.33 to 198.5 Urea mmol/L WMD = 1.61; 95% CI, 1.26 -1.96 WMD = 2.52; 95% CI, 1.26 - 3.78 WMD = 7.63; 95% CI, 6.52-8.74 Pulmonary function Smoker OR=1.61; 95% CI, 1.28-2.02 OR=13.04; 95% CI, 2.77-61.46 COPD OR = 3.70; 95% CI, 2.93-4.68 OR=9.2; 95% CI, 1.2-70.56 OR138 = 3.1; 95% CI, 2.6-4.2 Bilateral involvement of chest radiographs OR=4.65; 95% CI, 2.97-7.34 OR=5.85 95% CI, 3.74-9.15 OR138 =4.89; 95% CI,1.16-20.47 Liver function CLD OR = 1.48; 95% CI, 1.09-2.01 OR=25.35; 95% CI, 7.37-87.19 OR=2.36; 95% CI, 1.09-5.10 ALT, U/L WMD = 7.11; 95% CI, 5.47-8.75 WMD = 10.08; 95% CI, 0.89-19.27 WMD = -3.07; 95% CI, -11.26-5.11 AST, U/L WMD = 16.10; 95% CI, 14.00-18.20 WMD = 23.80; 95% CI, 11.32-36.29 WMD = 34.81; 95% CI, -4.39-74.02 Total bilirubin, mmol/L WMD = 2.75; 95% CI, 2.11- 3.40 WMD = 6.31; 95% CI, 2.07 - 10.55 WMD = 7.09; 95% CI, 2.09-12.09