Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

Zhao Lijun, Cao Jianzhong, Hu Kexin, He Xiaodong, Yun Dou, Tong Tanjun, Han Limin

Table 3 Functions and signaling pathway of sirtuins in aging.

Sirtuin Functions in aging Regulatory factor in signal pathway Positive Negative Yeast Sir2 Replicative lifespan extension Cell cycle arrest NAD+, mTOR, PKA, Sch9 C. elegans sir-2.1, sir-2.2, sir-2.3, sir-2.4 Lifespan extension, Stress resistance mTOR, HLH-30, PHA-4, NHR-62, WWP-1, KLF-1, EGL-9, DAF-16, AAK-2, HSF-1, FOXA, DAF-2, IGF-1, SKN-1, SAMS-1, RAB-10, DRR-1, DRR-2 UNC-51, ATG1, ULK1, BEC-1, ATG6, Beclin1, VPS-34, ATG-18, Wipi, ATG-7, ATG-8, IGG-1, HIF-1, TOR, RHEB-1, INS-7 Drosophila dSir2, Sirt4 Lifespan extension FOXO,4E-BP INR, p53, mTOR/S6K pathway Mammal sirt1 Lifespan extension, DNA repair, Cell cycle arrest, Cellular senescence eNOS, Erβ, FOXO3 PAI-1, p53, p16INK4a, NF-KB, p665hc, LKB1, Ciclin D1, mTOR/S6K pathway sirt 2 Cell cycle regulation BubR1, PPP, NAD+, FOXOs, Mn-SOD Wnt, AKT, NF-KB, sirt 3 Mitochondrial function, Oxidative stress, Centenarian-linked SNPs FOXO3A, Mn-SOD NF-KB, MAPK/ERK, P13K/AKt sirt 4 Fatty acid oxidation, Apoptosis NF-KB, Bax, Caspase, GDH, AMPK sirt 5 Fatty acid oxidation, Oxidative stress BCL, GDH, PDH sirt 6 Lifespan extension, DNA repair, Genome stability, Telomere maintenance Nrf2, eNOS, IGF/AKt, p53 P21Cip1/Waf1, NF-KB, ICM-1, PAI-1, sirt 7 Epigenetic regulation, Stress resistance, Apoptosis FOXO3 Myc, HIF-1a/2a, p53,