Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

Zhao Lijun, Cao Jianzhong, Hu Kexin, He Xiaodong, Yun Dou, Tong Tanjun, Han Limin

Table 5 The dual role of sirtuins in different cancer.

Oncogene/Tumor suppressor Expression in tumor tissue Up-regulated Down- regulated SIRT1 Both lung cancer, prostatic cancer, colon cancer, breast cancer, ovarian cancer, leukemia, neuroblastomas, osteo-sarcomas, and non-melanoma skin carcinomas early onset-mutant (BRCA1) breast cancer, beta-catenin-driven colon cancer model, sarcomas, lymphomas, teratomas, and carcinomas arising from deletion of p53, HFD-induced hepatocarcinomas, and age-associated spontaneous tumor development SIRT2 Both acute myeloid leukemia, pancreatic cancer, neuroblastoma, high-grade human HCC and prostate cancer glioma, liver cancer, and esophageal and gastric adenocarcinomas SIRT3 Both oral cancer 40% of human breast and ovarian cancers SIRT4 Tumor suppressor small cell lung carcinoma, gastric cancer, breast cancer and leukemia SIRT5 Both non-small cell lung cancer, ovarian carcinoma squamous cell carcinoma, endometrial carcinoma SIRT6 Both human skin squamous cell carcinoma and pancreatic, prostate and breast cancers head and neck squamous cell carcinoma, colon, pancreatic, liver and non-small cell lung cancers SIRT7 Oncogene thyroid cancer, hepatocellular carcinoma, bladder cancer and colorectal cancer