COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review

Neumann-Podczaska Agnieszka, Al-Saad Salwan R, Karbowski Lukasz M, Chojnicki Michal, Tobis Slawomir, Wieczorowska-Tobis Katarzyna

Table 2 Laboratory Findings.

Wang L et al. [10] Zhu X et al. [11] Lian J et al. [12] *Cheng B et al. [13] *Cheng B et al. [13] Chen T et al. [14] Liu K et al. [15] Godaert L et al. [16] Publication Month - 2020 Mar Mar Mar Apr Apr Apr Mar Apr Country China China China China China China China France No. Patients ≥60 Years Old 339 114 136 67 51 55 18 17 Age >60 >70 ≥60 ≥60 ≥60 ≥65 ≥60 >67 Male 166 67 58 22 31 34 12 8 Symptoms No. Table 1 Table 1 Table 1 Table 1 Table 1 Table 1 Table 1 Table 1 Comorbidities No. Outcome No. Laboratory Findings - Median (IQR) Cheng B. et al presented results as Mean with SD WBC Count (x109/L) 5.74 (4.37-8.29) 6.67 (4.56-9.05) 4.8 (3.9-6.4) - - 6.1 (2-25.7) 5.38 (4.33-6.13) - Lymphocyte Proportion % - - - - - - 19.15 (10.58-26.93) - Neutrophil Proportion % - - - - - - 68.3 (63.01-78.13) - Neutrophil Count (x109/L) 4.43 (2.76-6.62) 5.19 (3.101-7.803) 3.2 (2.5-4.4) 3.9+/-2.1 6.5+/-4.8 4.7 (1-21) - 4 x (<4.0) Lymphocytes Count (x109/L) 0.90 (0.59-1.29) 0.805 (0.55-1.17) 1.1 (0.7-1.4) 1.2+/-0.6 0.6+/-0.3 0.89 (0-6.0) - 13x (<1.5) ESR (mm/h) - - - 39.7+/-25.7 56.6+/-33.9 45 (9-96) - - C-reactive Protein (CRP) (mg/L) 49.6 (18.5-93.2) 59.1 (20.2-110.6) 19.0 (5.6-44.7) 30.8+/-37.1 123.5+/-109.0 85.3 (2-284) 22.74 (13.33-34.82) 16x(>10) Interleukin-6 (IL-6) (pg/mL) 10.9 (5.2-25.4) - - - - 1.4 (0-200) - - Procalcitonin (ng/mL) 0.08 (0.04-0.17) 0.104 (0.053-0.315) - - - 0.48 (0-8) 0.04 (0.02-0.09) - Albumin (g/L) - 33.85 (31.7-37) 39.2 (36.0-42.0) 38.6+/-4.9 33.1+/-5.0 33.3 (25-43) 33 (29-38) - Hemoglobin Hb (g/L) 121 (109-130) - 129.0 (120.3-140.8) - - - 107.35 (92.13-120.35) - Platelet Count (x109/L) 205 (151-259) - 169.5 (132.0-207.5) - - 162 (22-414) 207 (159-287) 7x(<15) Lactate dehydrogenase (LDH) (U/L) 301 (224-429) 328.5 (224-447) 244.0 (206.0-311.0) 262.0+/-249.8 453.4+/-266.8 395 (153-775) - - APTT (s) 28.5 (26.2-31.3) - - - - - - - PT (s) 12.1 (11.6-12.7) - - - - - - - D-Dimer (mg/L) 1.20 (0.62-3.25) 1.5 (0.725-5.465) - 0.95+/-1.35 4.59+/-7.13 1.35 (0.108-18.83) - - Cardiac Troponin (CtnI) (ng/mL) 0.010 (0.006-0.030) - - - - - - - Creatine Kinase (CK) (U/L) 63 (40-104) 66.5 (42-130) 74.5 (52.3-123.0) 88.6+/-56.7 287.3+/-500.4 141.2 (13-972) - - BUN (Blood Urea Nitrogen) (mmol/L) - 7.2 (4.92-9.7) 4.4 (3.6-5.9) 6.4+/-6.1 9.1+/-5.2 - - - Creatinine (μmol/L) 61 (50-76) 68 (57-96) 69.0 (58.6-79.6) 123.0+/-218.8 141.4+/-166.2 104.2 (37-787) 106.44 (79.83-150.79) - Alanine aminotransferase (ALT) (U/L) 27 (17-44) 32 (22-48) 21.0 (16.0-29.0) 25.1+/-19.0 32.4+/-32.7 41.3 (8-279) - - Aspartate aminotransferase (AST) (U/L) 32 (23-46) 32 (22-48) 28.0 (22.0-36.0) - - 63.1 (18-209) - - Liu Y et al. [17] Mi B et al. [18] Guo T et al. [24] **Sun H et al. [25] **Sun H et al. [25] Bruno G et al. [26] Yuan Y et al. [28] Publication Month - 2020 Mar Apr May May May May Mar Country China China China China China Italy China No. Patients ≥60 Years Old 7 6 105 123 121 31 4 Age >61 >75 ≥ 60 ≥ 60 ≥ 60 ≥65 64-71 Male 4 2 48 51 82 19 2 Symptoms No. Table 1 Table 1 Table 1 Table 1 Table 1 Table 1 4 Cough 2 Fever 2 Sputum Production 1 Sore throat Comorbidities No. 4 <82 GNRI** 1 HTN Outcome No. 4 Discharged Laboratory Findings - Median (IQR) WBC Count (x109/L) 5.24 (4.65-6.3) 10.43 (7.61-12.10) 4.9 (3.8-6.5) 5.37 (4.43-6.70) 10.15 (6.20-13.41) 6.43 (4.68-8.89) 5.37 (4.355-6.405) Lymphocyte Proportion % 19.8 (9.3-21) - - - - - 35.85 (25.43-44.75) Neutrophil Proportion % 74.8 (70-85.9) - - - - - 50.9 (46.175-58.25) Neutrophil Count (x109/L) 3.73 (3.33-5.39) 8.77 (5.8-11.10) 3.6 (2.6-4.5) - - - 2.755 (2.02-3.76) Lymphocytes Count (x109/L) 0.8 (0.51-0.87) 0.70 (0.5-1.03) 1.1 (0.7-1.4) 0.95 (0.70-1.34) 0.51 (0.35-0.72) 0.83 (0.61-1.19) 1.76 (1.61-1.83) ESR (mm/h) - - - 36.0 (20.0-59.0) 37.0 (20.0-60.0 - - C-reactive Protein (CRP) (mg/L) 52.95 (45.6-69.3) 25.95 (17.8-48.75) 33.6 (9.4-56.9) 39.8 (8.3-79.6) 105.4 (65.0-165.2) 79.2 (34.7-133.5) 4.7 (4.31-4.91) Interleukin-6 (IL-6) (pg/mL) - - - 12.7 (3.3-41.5) 75.2 (35.2-162.9) - - Procalcitonin (ng/mL) 0.077 (0.044-0.167) 0.49 (0.22-1.95) - 0.05 (0.03-0.09) 0.36 (0.14-1.01) 0.12 (0.07-0.18) 3x(<0.10) / 0.13 Albumin (g/L) 38.3 (35.95-40.55) 33.9 (33.5-36.33) 36.2 (33.3-39.1) - - - - Hemoglobin Hb (g/L) - - 125 (115-136) - - 12.5 (11.7-14.2) - Platelet Count (x109/L) 119 (118-141) 153 (144-178) 171.0 (135.8-228.8) - - 193 (143-293) - Lactate dehydrogenase (LDH) (U/L) 662 (551.5-708) - 208.8 (173.1-239.4) - - 268 (213.5-335) 180 (166.75-183.25) APTT (s) - 31.98 (31.34-34.68) 33.9 (30.0-37.9) - - - - PT (s) - 13.18 (12.39-13.78) 12.5 (11.4-13.1) - - - - D-Dimer (mg/L) - 12.45 (7.04-15.88) 0.6 (0.3-1.9) 0.79 (0.47-1.63) 4.16 (1.49-21.00) - 73.5 (54.5-99.5) Cardiac Troponin (CtnI) (ng/mL) 0.012 (0.012-0.012) - - - - - 2 x (<0.010) Creatine Kinase (CK) (U/L) 107.5 (84.25-307.5) - 84.5 (53.1-143.4) - - - 62 (50-66.5) BUN (Blood Urea Nitrogen) (mmol/L) 5.37 (4.64-6.2) 8.74 (6.2-16.01) 5.5 (4.2-7.3) - - 2.8 (2.1-4.1) - Creatinine (μmol/L) 81.9 (50.3-113) 96 (80.5-128) 66.9 (55.0-80.0) 66 (54-82) 90 (76-118) 89.3 (67.2-108.76) - Alanine aminotransferase (ALT) (U/L) 26.6 (26.25-37.15) 15 (15-17.25) 19.8 (15.0-28.3) 22 (14-36) 28 (19-42) - - Aspartate aminotransferase (AST) (U/L) 33.6 (26.45-47.05) 32 (27.5-37.25) 26.0 (20.9-33.9) 28 (20-39) 45 (30-64) - 18.6 (16.675-23)