Emotional Lability at Disease Onset Is an Independent Prognostic Factor of Faster Disease Progression in Amyotrophic Lateral Sclerosis

Barć Krzysztof, Szacka Katarzyna, Nieporęcki Krzysztof, de Carvalho Mamede, Gromicho Marta, Grosskreutz Julian, Petri Susanne, Rödiger Annekathrin, Steinbach Robert, Uysal Hilmi, Kuźma-Kozakiewicz Magdalena

Table 1 Patients’ baseline characteristics.

All patients (n=1145) ELO(+) group (n=199) ELO(-) group (n=946) p-value Demographic characteristics Gender (%) Female Male 44.28 55.72 51.76 48.24 42.71 57.29 <0.05* Age at time of evaluation (years ± SD) 61.6±12.79 61.7±12.32 61.6±12.89 =0.93* Disease characteristics Site of onset (%) Bulbar Limb 27.25 72.75 45.73 54.27 23.36 76.64 <0.0001* Emotional lability at onset (%) Yes No 17.38 82.62 100 - - 100 - Cognitive impairment at onset (%) Yes No 11.70 88.30 32.16 67.84 7.40 92.60 <0.0001* Initial weight loss (%) Yes No 17.47 82.53 29.15 70.85 15.00 85.00 <0.0001*