Emotional Lability at Disease Onset Is an Independent Prognostic Factor of Faster Disease Progression in Amyotrophic Lateral Sclerosis

Barć Krzysztof, Szacka Katarzyna, Nieporęcki Krzysztof, de Carvalho Mamede, Gromicho Marta, Grosskreutz Julian, Petri Susanne, Rödiger Annekathrin, Steinbach Robert, Uysal Hilmi, Kuźma-Kozakiewicz Magdalena

Table 2 ALSFRS-R decline rate in terms of bulbar, motor, and respiratory function subscore.

ALSFRS-R bulbar subscore decline rate (median) p-value* ALSFRS-R motor subscore decline rate (median) p-value* ALSFRS-R respiratory subscore decline rate (median) p-value* ELO(+) ELO(-) ELO(+) ELO(-) ELO(+) ELO(-) All patients 0.21 0.06 <0.0001 0.39 0.34 =0.14 0.03 0.00 <0.005 Bulbar onset patients 0.39 0.31 <0.05 0.33 0.23 =0.16 0.08 0.00 <0.05 Limb onset patients 0.07 0.01 <0.0001 0.43 0.36 =0.06 0.00 0.00 =0.41