Emotional Lability at Disease Onset Is an Independent Prognostic Factor of Faster Disease Progression in Amyotrophic Lateral Sclerosis

Barć Krzysztof, Szacka Katarzyna, Nieporęcki Krzysztof, de Carvalho Mamede, Gromicho Marta, Grosskreutz Julian, Petri Susanne, Rödiger Annekathrin, Steinbach Robert, Uysal Hilmi, Kuźma-Kozakiewicz Magdalena

Table 3 The comparison of ALSFRS-R decline rates between patients with and without emotional lability at disease onset in terms of disease onset, weight loss and gender.

ALSFRS-R decline rate (median) p-value* ELO(+) (n=199) ELO(-) (n=946) All patients 0.70 0.50 <0.0001 Bulbar onset Limb onset 0.80 0.59 0.65 0.46 <0.05 <0.01 Weight loss at onset Stable weight at onset 0.83 0.64 0.65 0.48 <0.05 <0.001 Female Male 0.78 0.61 0.56 0.48 <0.001 <0.05