Trends in LDL-C and Non-HDL-C Levels with Age

Zhang Peng, Su Qian, Ye Xiaomiao, Guan Ping, Chen Chengjun, Hang Yanwen, Dong Jian, Xu Zhongjie, Hu Wei

Table 2 Associations with LDL-C level evaluated by univariate linear regression analyses.

Female Male Variable Coef. 95% CI P Variable Coef. 95% CI P Pooled Age 0.016 0.015~0.016 <0.001 Age 0.003 0.002~0.003 <0.001 Systolic BP / / / Systolic BP / / / Diastolic BP 0.007 0.003~0.012 <0.001 Diastolic BP 0.005 0.002~0.009 <0.001 Glucose (mmol/L) 0.091 0.023~0.132 <0.001 Glucose (mmol/L) 0.082 0.045~0.124 0.003 BMI (kg/m2) 0.031 0.022~0.044 0.001 BMI (kg/m2) 0.041 0.032~0.056 <0.001 Inactive lifestyle 0.023 0.019~0.038 0.002 Inactive lifestyle 0.031 0.019~0.044 0.003 Moderate drinking / / / Moderate drinking 0.044 0.032~0.056 0.003 Smoking / / / Smoking 0.056 0.045~0.077 0.001 Age-stratified Age phase I: 18 ≤ age ≤ 56 (N = 61,420) Age phase I: 18 ≤ age ≤ 33 (N = 22,942) Age 0.020 0.020~0.021 <0.001 Age 0.026 0.023~0.029 <0.001 Systolic BP / / / Systolic BP / / / Diastolic BP 0.004 0.001~0.008 <0.001 Diastolic BP / / / Glucose (mmol/L) 0.114 0.098~0.143 0.002 Glucose (mmol/L) 0.154 0.137~0.176 0.001 BMI (kg/m2) 0.039 0.028~0.051 0.003 BMI (kg/m2) 0.063 0.048~0.079 <0.001 Inactive lifestyle 0.048 0.039~0.066 <0.001 Inactive lifestyle 0.023 0.019~0.033 0.004 Moderate drinking / / / Moderate drinking 0.032 0.023~0.054 <0.001 Smoking / / / Smoking 0.066 0.056~0.076 <0.001 Age phase II: 34 ≤ age ≤ 56 (N = 59,807) Age 0.002 0.001~0.003 <0.001 Systolic BP / / / Diastolic BP 0.008 0.004~0.011 0.002 Glucose (mmol/L) 0.032 0.021~0.039 <0.001 BMI (kg/m2) 0.029 0.019~0.045 0.002 Inactive lifestyle 0.016 0.012~0.023 0.002 Moderate drinking 0.056 0.043~0.077 <0.001 Smoking 0.103 0.078~0.201 0.003 Age phase II: age ≥ 57 (N = 8,748) Age phase III: age ≥ 57 (N = 15,653) Age -0.013 -0.010 ~ -0.007 <0.001 Age -0.008 -0.010 ~ -0.007 <0.001 Systolic BP / / / Systolic BP / / / Diastolic BP 0.013 0.009~0.017 <0.001 Diastolic BP 0.004 0.001~0.008 0.027 Glucose (mmol/L) 0.049 0.032~0.076 <0.001 Glucose (mmol/L) 0.029 0.021~0.043 0.003 BMI (kg/m2) 0.017 0.012~0.032 <0.001 BMI (kg/m2) 0.019 0.011~0.044 <0.001 Inactive lifestyle 0.018 0.012~0.033 0.003 Inactive lifestyle 0.023 0.014~0.033 <0.001 Moderate drinking / / / Moderate drinking 0.021 0.014~0.034 <0.001 Smoking / / / Smoking 0.018 0.016~0.034 0.003