Clinical Factors Associated with Progression and Prolonged Viral Shedding in COVID-19 Patients: A Multicenter Study

Feng Zhichao, Li Jennifer, Yao Shanhu, Yu Qizhi, Zhou Wenming, Mao Xiaowen, Li Huiling, Kang Wendi, Ouyang Xin, Mei Ji, Zeng Qiuhua, Liu Jincai, Ma Xiaoqian, Rong Pengfei, Wang Wei

Table 2 Clinical risk factors associated with development of severe or critical illnesses.

Variables Univariate OR (95% CI) P value Multivariate OR (95% CI) P value Age 1.06 (1.04-1.08) < 0.001 1.04 (1.02-1.07) < 0.001 Male gender 1.33 (0.80-2.20) 0.275 Smoking history 1.80 (0.83-3.92) 0.136 Hypertension 3.11 (1.75-5.55) < 0.001 0.064 Diabetes 2.95 (1.44-6.03) 0.003 0.159 Cardiovascular disease 2.85 (1.08-7.56) 0.035 0.807 COPD 13.81 (4.85-39.38) < 0.001 7.53 (2.44-23.26) < 0.001 Obesity 1.98 (0.94-4.18) 0.072 0.060 Age 1.06 (1.04-1.08) < 0.001 1.04 (1.02-1.06) < 0.001 Male gender 1.33 (0.80-2.20) 0.275 Smoking history 1.80 (0.83-3.92) 0.136 Hypertension < 0.001 0.046 Non-hypertensive Reference 1 Reference 1 Hypertensive on AECI/ARB therapy 0.60 (0.08-4.66) 0.628 0.51 (0.06-3.99) 0.517 Hypertensive on other therapy 3.93 (2.15-7.19) < 0.001 2.29 (1.14-4.59) 0.020 Diabetes 2.95 (1.44-6.03) 0.003 0.210 Cardiovascular disease 2.85 (1.08-7.56) 0.035 0.944 COPD 13.81 (4.85-39.38) < 0.001 7.55 (2.44-23.39) < 0.001 Obesity 1.98 (0.94-4.18) 0.072 0.086