Clinical Factors Associated with Progression and Prolonged Viral Shedding in COVID-19 Patients: A Multicenter Study

Feng Zhichao, Li Jennifer, Yao Shanhu, Yu Qizhi, Zhou Wenming, Mao Xiaowen, Li Huiling, Kang Wendi, Ouyang Xin, Mei Ji, Zeng Qiuhua, Liu Jincai, Ma Xiaoqian, Rong Pengfei, Wang Wei

Table 4 Clinical risk factors associated with prolonged viral shedding.

Variables Univariate HR (95% CI) P value Multivariate HR (95% CI) P value Age 1.01 (1.00-1.01) 0.032 0.770 Male gender 1.15 (0.97-1.39) 0.102 1.22 (1.02-1.46) 0.030 Smoking history 0.83 (0.60-1.12) 0.227 Any comorbidity 1.25 (1.02-1.54) 0.028 0.202 Hypertension 0.106 0.502 Non-hypertensive Reference 1 1 Hypertensive on AECI/ARB therapy 0.63 (0.37-1.08) 0.095 0.383 Hypertensive on other therapy 0.82 (0.62-1.08) 0.159 0.485 Diabetes 0.99 (0.72-1.39) 0.976 Cardiovascular disease 1.29 (0.82-2.02) 0.268 COPD 0.74 (0.44-1.24) 0.248 Obesity 1.23 (0.90-1.69) 0.197 Severe or critical illnesses 1.52 (1.16-1.96) 0.002 0.340 Lopinavir/ritonavir treatment within 7 days from illness onset 0.80 (0.67-0.95) 0.013 0.75 (0.63-0.90) 0.002 Systematic glucocorticoid therapy 1.67 (1.35-2.04) < 0.001 1.79 (1.46-2.21) < 0.001 Invasive mechanical ventilation 1.96 (1.16-3.23) 0.011 0.877