Clinical Factors Associated with Progression and Prolonged Viral Shedding in COVID-19 Patients: A Multicenter Study

Feng Zhichao, Li Jennifer, Yao Shanhu, Yu Qizhi, Zhou Wenming, Mao Xiaowen, Li Huiling, Kang Wendi, Ouyang Xin, Mei Ji, Zeng Qiuhua, Liu Jincai, Ma Xiaoqian, Rong Pengfei, Wang Wei

Table 5 Clinical risk factors associated with prolonged viral shedding according to disease severity.

Variables Severe or critical Mild or moderate Multivariate HR (95% CI) P value Multivariate HR (95% CI) P value Age 1.04 (1.02-1.06) 0.001 0.362 Male gender 0.481 1.21 (1.00-1.47) 0.049 Smoking history 0.445 0.473 Any comorbidity 0.924 0.506 Hypertension 0.535 0.577 Non-hypertensive 1 1 Hypertensive on AECI/ARB therapy 0.955 0.299 Hypertensive on other therapy 0.266 0.824 Diabetes 0.888 0.663 Cardiovascular disease 0.121 0.292 COPD 0.499 0.894 Obesity 0.813 0.174 Lopinavir/ritonavir treatment within 7 days from illness onset 0.414 0.76 (0.62-0.92) 0.005 Systematic glucocorticoid therapy 1.85 (1.05-3.26) 0.034 1.69 (1.32-2.17) < 0.001 Invasive mechanical ventilation 0.409 —