Stem Cell Based Therapy Option in COVID-19: Is It Really Promising?
Irmak Duygu Koyuncu, Darıcı Hakan, Karaöz Erdal
Table 3 The randomised controlled trials along with their development phases, participant size blinding status and the treatment intervention types to cure SARS-CoV infection in ICTP database of WHO.
Protocol design: Selected Trials with Randomized Controlled Design
Trial IDPhase / Target participantsBlindingIntervention
ChiCTR2000029569Phase 0 /
30 subjects		Open labelExperimental group: conventional treatment combined with umbilical cord mesenchymal stem cellconditioned medium group
Control group: Conventional treatment
NCT04339660Phase 1-2 /
30 Subjects		Triple-blindedExperimental group: conventional and treatment with umbilical cord MSCs,
1x106 UC-MSCs /kg body weight suspended in 100mL saline Control group: conventional treatment and Placebo intravenously. Placebo 100mL saline intravenously
NCT04336254Phase 1-2 /
20 Subjects		Triple-blindedExperimental group: allogeneic human dental pulp stem cells
Intravenous injection of 3.0x107 human dental pulp stem cells solution (30ml) on day 1, day 4 and day 7, based on routine treatment of COVID-19 Control group: Intravenous saline injection as Placebo Intravenous injection of 3ml of 0.9% saline on day 1, day 4 and day 7, based on routine treatment of COVID-19
NCT04288102Phase 2 /
90 Subjects		Quadruple-blindedExperimental Group: Conventional treatment plus 3 times of MSCs(4.0x107 cells per time) intravenously at Day 0, Day 3, Day 6.
Control Group: Saline containing 1% Human serum albumin (solution of MSC) 3 times of placebo (intravenously at Day 0, Day 3, Day 6)Other: Intravenous saline injection (Placebo) Intravenous injection of 3ml of 0.9% saline on day 1, day 4 and day 7, based on routine treatment of COVID-19
ChiCTR2000030138Phase 2 /
60 subjects		Double BlindedExperimental group: Intravenous injection of human umbilical cord mesenchymal stem cells (UC-MSC); Note: routine treatment combination was not mentioned in the other records.
Control Group: Routine treatment + placebo