A Glimmer of Hope: Maintain Mitochondrial Homeostasis to Mitigate Alzheimer’s Disease

Li Wenbo, Kui Ling, Demetrios Tsirukis, Gong Xun, Tang Min

Table 1 Summary of different pathways and genes/proteins involved in autophagy/mitophagy.

Pathways Genes/Proteins Refs The PINK1/Parkin-dependent pathway PINK1, Parkin, USP8, USP30, AMBRA1, Bcl2, FUNDC1, MUL1, Nix, ATG5, LC3 [74, 119] The Parkin-independent pathway PINK1 [120] The Reticulocyte pathway Nix, LC3 [60] The Zygote pathway VCPs, MUL1, LC3 [121-123] The MDVs pathway PINK1, Parkin, LC3 [124] The mTOR pathway ULK1, Atg1, Atg13, Akt, PKC, FOXO3 [45]