Alteration of Metabolic Profile and Potential Biomarkers in the Plasma of Alzheimer’s Disease

Shao Yaping, Ouyang Yang, Li Tianbai, Liu Xinyao, Xu Xiaojiao, Li Song, Xu Guowang, Le Weidong

Table 2 Results for assessment of plasma metabolite panel in the discrimination of AD/MCI.

Metabolite panel AUC 95% CI Sensitivity Specificity SE Significance Meta+age AD vs. Ctrl 0.840 0.740 ~ 0.941 76.7% 83.3% 0.0512 8.57E-07 AD vs. (Ctrl+NDC) 0.831 0.733 ~ 0.928 86.5% 70.0% 0.0496 1.39E-07 Allocholic acid MCI vs. Ctrl 0.766 0.604 ~ 0.928 69.2% 83.7% 0.0827 3.95E-03 MCI vs. (Ctrl+NDC) 0.745 0.591 ~ 0.900 69.2% 77.0% 0.0787 4.96E-03 CA MCI vs. Ctrl 0.758 0.585 ~ 0.932 61.5% 88.4% 0.0887 5.04E-03 MCI vs. (Ctrl+NDC) 0.770 0.612 ~ 0.928 61.5% 87.8% 0.0807 1.96E-03 CDCA MCI vs. Ctrl 0.850 0.721 ~ 0.979 76.9% 90.7% 0.0659 1.48E-04 MCI vs. (Ctrl+NDC) 0.839 0.705 ~ 0.973 76.9% 89.2% 0.0684 1.04E-04