Influence of BDNF Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases

Urbina-Varela Rodrigo, Soto-Espinoza María Inés, Vargas Romina, Quiñones Luis, del Campo Andrea

Table 1 BDNF polymorphisms and their relationship with multiple diseases. Each polymorphism was looked up in SNPedia and verified in the reference.

SNPs Position in Chromosome Nucleotide Change Protein effect Related diseases rs10767664 27.704.439 T/A Intron variant Asthma [6] Allergic Rhinitis [73] Obesity [67] rs10835210 27.654.363 C/A/G Intron variant Schizophrenia [105] rs11030100 27.656.039 C/T 3'UTR variant Asthma [104] rs11030101 27.659.197 A/T 5'UTR variant Depression Asthma [104] Bipolar disorder [74] rs11030103 27.660.786 A/G Intron variant Depression and Suicide [59] rs11030104 27.662.970 A/G Intron variant Panic attacks Bipolar disorder Alzheimer disease [50] rs11030107 27.673.288 A/G Intron variant Bipolar Disorder [83] rs12273363 27.723.312 T/C Intron variant Major Depressive Disorder[46] Bipolar disorder rs12273539 27.661.764 C/T Intron variant Depression and suicide rs12291063 27.672.554 T/C Intron variant Obesity [16] rs13306221 27.701.142 C/T Intron variant Alcohol dependency [100] Heroin dependency [52] rs16917237 27.680.836 G/T Intron variant Bipolar Disorder [102] Asthma rs2030323 27.706.992 A/C Intron variant Obesity [35] [36] rs2030324 27.705.368 A/G Intron variant Alzheimer Disease [26] Parkinson Disease [95] PTSD [41] rs2049045 27.672.694 G/A/C Intron variant Bipolar Disorder rs2049046 27.702.228 T/A Intron variant Obsesive Compulsive disorder rs28722151 27.659.629 C/G 5´ UTR Depression and suicide rs41282918 27.657.233 A/C 3´ UTR Depression and suicide rs6265 27.658.369 G/A Missense variant G196A Val 66 Met Major Depressive disorder Hypertension AD PD T2D Depression Asthma Allergic Rhinitis rs7103411 27.678.578 C/T Intron variant PTSD Epilepsy [41] rs7103873 27.678.770 G/A/C Intron variant Depression [65] rs7127507 27.693.337 T/C Intron variant Hippocampal Volume in cerebral injury [44] rs8192466 27.658.560 G/A/T Missense variant Thr2 Ile Schizophrenia rs962369 27.712.873 T/C Intron variant Depression and suicide [72] rs988748 27.703.198 C/G Intron variant Depressive disorder Bipolar disorder [88]