Oxidative Stress at the Crossroads of Aging, Stroke and Depression

Shao Anwen, Lin Danfeng, Wang Lingling, Tu Sheng, Lenahan Cameron, Zhang Jianmin

Table 3 Co-antioxidants in stroke and depression from experiments.

Co-antioxidants in stroke and depression from experiments Antioxidants Stroke Depression Ischemic stroke ICH SAH adiponectin ✔ ✔ ECGG ✔ ✔ metformin ✔ ✔ protocatechualdehyde ✔ ✔ Sirt3 ✔ ✔ curcumin ✔ ✔ DHC/A ✔ ✔ mangiferin ✔ ✔ progesterone ✔ ✔ UA ✔ ✔ dl-3-n-Butylphthalide ✔ ✔ quercetin ✔ ✔ resveratrol ✔ ✔ baicalein ✔ ✔ allicin ✔ ✔ melatonin ✔ ✔ ✔ ✔ Clinical trials and outcomes in stroke Clinical trials and outcomes in depression Types Outcomes Types Outcomes flavonoid meta-analysis high flavonoid reduces risk of stroke RCT higher flavonoid links to lower depression risk especially among women UA RCT and URICOICTUS UA is safe; UA enhances outcomes of stroke cohort studies and meta-analysis UA are associated with low risk of depression hospitalization and lower MDA levels melatonin RCT early melatonin usage ameliorates the brain injury of asphyxial newborns RCT buspirone-melatonin therapy benefits cognitive function Review melatonin does not affect mood disorders