The Application of Artificial Intelligence in the Genetic Study of Alzheimer’s Disease
Mishra Rohan, Li Bin
Table 1 Genetic risk factors for AD revealed by AI analysis exclusively
Genetic risk factors for ADBiological processes [https://www.genecards.org/]
ANKRD36C [118]Ion channel inhibitor activity
BCR [115]Protein tyrosine kinase activity, macrophage functions,
C4B [109]Inflammation
CACNA1C [118]Voltage-dependent calcium channel
CD109 [112]Inflammation
CD69 [108]Inflammation
CLCN3 [118]Voltage-gated chloride channel
CR2 [109]Inflammation
DAPK1 [111]Apoptosis modulation and signaling
DHRSX [118]Autophagy
DPYD [112]Uracil and thymidine catabolism.
ENTPD7 [111]Oxidative stress and DNA damage
EPS8 [109]Regulator of axonal filopodia formation in neurons
FGF14 [118]Nervous system development
GALNT18 [118]O-linked oligosaccharide biosynthesis
GFRA1 [118]Glial cell line-derived neurotrophic factor receptor family
HSPA2 [109]Molecular chaperone implicated in a wide variety of cellular processes
IL1B [111]Inflammation
ITGBL1 [118]EGF-like protein family
LOC101928478 [118]Long intergenic non-protein coding RNA
LOC442028 [118]Long intergenic non-protein coding RNA
MAF1 [118]Repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions
MEF2D [112]Cell growth, survival and apoptosis
NIPA1 [118]Magnesium transporter that may play a role in nervous system development and maintenance.
NPC2 [115]Transport of cholesterol
NTM [112]Neural cell adhesion molecule
NTNG2 [112]Neurite outgrowth of both axons and dendrites
OR11H4 [118]Odorant receptor
PCDHA [116]Cell surface proteins of neurons and synaptic junctions
PHACTR3 [108]Nuclear scaffold in proliferating cells
PPA1 [118]Respiratory electron transport and ATP synthesis
PRNP [111]Neuronal development and synaptic plasticity
PTPN2 [109]Cell growth, differentiation and mitotic cycle
PVRL2 [112]Cell junction organization and adherens junction
RFTN1 [115]Inflammation
RIMS1 [118]Synaptic vesicle exocytosis
SHARPIN [109]Inflammation
SLC12A1 [112]Sodium-potassium-chloride cotransporter
SORCS1 [111]Neuropeptide receptor activity
SORCS2 [118]Receptor for the precursor forms of NGF and BDNF
STRAP [109]kinase activity
STUB1 [109]Inflammation
TUBB2B [109]Isoform of tubulin
UNC5B [112]Axon guidance