A Perspective on Roles Played by Immunosenescence in the Pathobiology of Alzheimer's Disease

Zhao Yan, Zhan Jun-Kun, Liu Youshuo

Table 2 Novel treatments for AD to reverse immunosenescence.

Drug classification agent Mechanism of action Ref. Antimicrobial therapy Antibiotic treatment Avoid bacterial infections [122] Antiviral agent Protects against virus infections [125,126] GV-971 Regulate gut flora imbalance and reshape immune homeostasis [124] Anti-inflammatory treatment Anti-inflammatory drugs Modulate inflammatory processes [128] Immunotherapy Antiamyloid agents Remove amyloid and prevent amyloid production and aggregation [131] Anti-tau agents Reduce tau-mediated neuronal damage [131] immunomodulators cytokines, complement components, and histocompatibility proteins Improve cell signaling [132] Anti-aging strategy Geroprotectors Slow the rate of biological aging [134] Young blood Modulate aging and rejuvenate organs [135,136] Inhibition of mTOR Improve vaccine response [137]