The Critical Role of SIRT1 in Parkinson’s Disease: Mechanism and Therapeutic Considerations

Li Xuan, Feng Ya, Wang Xi-Xi, Truong Daniel, Wu Yun-Cheng

Table 2 Sirtuin activators and their clinical applications (except Parkinson’s disease).

Compound name Clinical applications References Resveratrol Cardiovascular disease, atherosclerosis, diabetes, sleep disorders, AD, cancer Zordoky et al. [118], Agarwal et al. [119], Seyyedebrahimi et al. [120], Pennisi et al. [121], Moussa et al. [122], Banaszewska et al. [123] SRT2104, SRT1720, SRT2183, SRT1460 E6155 P7C3 and its analog Type 2 diabetes, ulcerative colitis, psoriasis, effect on lipid parameters Diabetes AD, ALS, traumatic brain injury, acute liver injury, ischemic stroke, optic nerve injury Baksi et al. [124], Sands et al. [125], Krueger et al. [126], Venkatasubramanian et al.[127] Liu et al. [89] Voorhees et al.[128], Tesla et al.[129], Blaya et al. [130], Zhang et al. [131],Oku et al. [132], Wang et al. [133]