Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging

Yu-Qing Ni, Xiao Lin, Jun-Kun Zhan, You-Shuo Liu

Table 1 Exosomal non-coding RNAs implicated in ECs functions.

Exosomal non-coding RNAs Cargos Targets ECs functions Reference Exosomal miRNAs miR-122-5p HGF pro-proliferation, pro-migration [23] miR-210-3p HGF pro-proliferation, pro-migration [23] miR-296-5p HGF pro-proliferation, pro-migration [23] miR-376c-3p HGF pro-proliferation, pro-migration [23] miR-214 ATM pro-proliferation, anti-senescence, pro-angiogenesis [24] miR-17 ANGPT1 STAT3 pro-proliferation, pro-migration, anti-inflammation [25] [35] miR-19 ANGPT1 pro-proliferation, pro-migration [25] miR-20a ANGPT1 pro-proliferation, pro-migration [25] miR-30c ANGPT1 pro-proliferation, pro-migration [25] miR-126 ANGPT1 pro-proliferation, pro-migration [25] miR-92a SOCS5 anti- proliferation, pro-inflammation [26] [30] miR-21 RhoB anti- proliferation, pro-inflammation [27] [31] miR-24 Sp1 anti- proliferation [28] miR-15a VEGF, NF-kB pro-inflammation [32, 33] miR-27a VEGF, EGFR pro-inflammation [32, 33] miR-34a BCL2, SIRT1 pro-inflammation [32, 33] miR-223 ICAM-1 anti-inflammation [34] miR-125a DLL4 pro-angiogenesis [36] miR-181b-5p TRPM7 pro-angiogenesis [37] miR-106b-5p ANG2 anti- angiogenesis [38] miR-320 IGF-1, Hsp20, Ets2 anti- angiogenesis [39] Exosomal lncRNAs HOTTIP cyclin D1, PCNA pro-proliferation, pro-migration [48] POU3F3 bFGF, VEGF pro-proliferation, pro-migration, pro-angiogenesis [49] MALAT1 IL-6, TNF-α, SAA3 anti- proliferation, pro-migration, pro-inflammation [50] [59, 60] HOTAIR VEGF pro-angiogenesis [53] H19 Unknown pro-angiogenesis [54] CCAT2 TGFβ, Bcl-2 pro-angiogenesis, anti-apoptosis [55] Meg3 Unknown anti- angiogenesis [57] GAS5 P53, Caspase 3, Caspase 7 pro-apoptosis [58]