Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging

Yu-Qing Ni, Xiao Lin, Jun-Kun Zhan, You-Shuo Liu

Table 2 Exosomal non-coding RNAs implicated in VSMCs functions.

Exosomal non-coding RNAs Cargos Targets ECs functions Reference Exosomal miRNAs miR-31 MAPK/ERK, LATS2 promote phenotype transition [63] miR-133 Sp1 promote phenotype transition [64] miR-223 MEF2C, RhoB promote phenotype transition [65] miR-26a Smad1 inhibit phenotype transition [66] miR-21 BCL2 pro-proliferation [67] miR-130a BMP2, TGFβ1 pro-proliferation [68] miR-221/222 p27, p57 pro-proliferation [69, 70] miR-152 DNMT1 anti-proliferation [73] miR-155 Ets1 anti-proliferation [74] miR-223 PDGFRβ anti-proliferation [75] miR-339 PDGFRβ anti-proliferation [75] miR-21 PDGFRβ anti-proliferation [75] miR-29b DNMT3b pro-migration [78] miR-143-3p TGFβ pro-migration, pro-angiogenesis [79] miR-712 NCKX4 pro-calcification [80] miR-714 PMCA1 pro-calcification [80] miR-762 NCX1 pro-calcification [80] miR-29a/b ADAMTS-7 anti-calcification [83] miR-125b Ets1, Osterix anti-transdifferentiation, anti-calcification [84, 85] miR-126-3p VEGF, ANG1, ANG2, MMP9, TSP1 pro-angiogenesis [86] miR-92a MKK4 anti-apoptosis, anti-senescence [88] miR-34a SIRT1 pro-senescence [89] Exosomal lncRNAs MALAT1 Unknown pro-proliferation, pro-migration [92] MEG3 p53 anti-proliferation, anti-migration [93] lncRNA-p21 p53 anti-proliferation, pro-apoptosis [94] HOTAIR ALPL, BMP2 anti-calcification [95]