Predictive Value of Pin1 in Cervical Low-Grade Squamous Intraepithelial Lesions and Inhibition of Pin1 Exerts Potent Anticancer Activity against Human Cervical Cancer

Yan-Tong Guo, Yan Lu, Yi-Yang Jia, Hui-Nan Qu, Da Qi, Xin-Qi Wang, Pei-Ye Song, Xiang-Shu Jin, Wen-Hong Xu, Yuan Dong, Ying-Ying Liang, Cheng-Shi Quan

Table 2 Pin1 and c-Jun statuses according to Age, Lymph node status, Tumor size, P16 and Ki67.

Characteristics No. Pin1 status P value C-jun statuses P value Negative No. (%) Positive No. (%) Negative No. (%) Positive No. (%) Age (years) <50 10 4 6 0.724 1 9 0.662 ≥50 18 6 12 1 17 Lymph node status Absent 22 10 12 0.039 2 20 0.443 Present 6 0 6 0 6 Tumor size ≤4 cm 25 9 16 0.927 2 23 0.611 >4 cm 3 1 2 0 3 p16 Negative 0 0 0 NA 0 0 NA Positive 28 10 18 2 26 Ki67 1%-25% 0 0 0 0.014 0 0 <0.001 25%-50% 0 0 0 0 0 50%-75% 3 3 0 2 1 >75% 25 7 18 0 25