COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile

Fulzele Sadanand, Sahay Bikash, Yusufu Ibrahim, Lee Tae Jin, Sharma Ashok, Kolhe Ravindra, Isales Carlos M

Table 5 Human miRNAs targeting the COVID-19 genome regulating KEGG pathway.

KEGG pathway p-value #genes #miRNAs Proteoglycans in cancer 5.75E-08 145 76 Hippo signaling pathway 1.04E-07 113 74 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 6.54E-07 57 72 Adherens junction 6.54E-07 62 75 Renal cell carcinoma 2.40E-06 56 74 Wnt signaling pathway 2.99E-06 107 76 Fatty acid biosynthesis 1.25E-05 9 50 ECM-receptor interaction 1.25E-05 56 70 Axon guidance 1.58E-05 94 75 FoxO signaling pathway 4.68E-05 100 76 Ubiquitin mediated proteolysis 5.75E-05 102 76 Pathways in cancer 6.76E-05 275 76 ErbB signaling pathway 8.02E-05 66 75 Pancreatic cancer 0.000165 53 73 TGF-beta signaling pathway 0.000234 57 73 Focal adhesion 0.000234 147 74 Rap1 signaling pathway 0.000234 148 76 Gap junction 0.000753 64 76 Long-term depression 0.000962 45 73 N-Glycan biosynthesis 0.001119 33 69 Prion diseases 0.001166 20 66 Endocytosis 0.001469 140 75 Fatty acid metabolism 0.001547 31 69 Endometrial cancer 0.001567 41 72 Signaling pathways regulating pluripotency of stem cells 0.001567 99 76 Prostate cancer 0.001769 66 75 Colorectal cancer 0.002458 49 72 Cell cycle 0.002703 89 73 PI3K-Akt signaling pathway 0.002703 225 76 Melanoma 0.00405 54 73 Circadian rhythm 0.00591 26 70 Prolactin signaling pathway 0.006364 50 75 Adrenergic signaling in cardiomyocytes 0.006716 97 77 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.006964 17 62 Dorso-ventral axis formation 0.011682 23 73 AMPK signaling pathway 0.012171 87 75 Glioma 0.012308 45 72 Tight junction 0.012616 98 76 Thyroid hormone signaling pathway 0.01495 79 72 Morphine addiction 0.01495 63 73 Oocyte meiosis 0.01495 79 75 Ras signaling pathway 0.01495 145 76 Lysine degradation 0.016507 33 66 Amphetamine addiction 0.016687 45 72 Sphingolipid signaling pathway 0.016687 79 76 Glutamatergic synapse 0.016687 77 76 mRNA surveillance pathway 0.01713 64 74 RNA transport 0.01833 112 75 MAPK signaling pathway 0.018745 166 77 Chronic myeloid leukemia 0.01925 51 74 Estrogen signaling pathway 0.022066 65 76 GABAergic synapse 0.023522 59 73 p53 signaling pathway 0.026352 48 73 Biosynthesis of unsaturated fatty acids 0.027342 15 49 mTOR signaling pathway 0.031797 45 70 Regulation of actin cytoskeleton 0.037298 139 75 Protein processing in endoplasmic reticulum 0.038084 112 74 cAMP signaling pathway 0.038084 130 76 Oxytocin signaling pathway 0.038084 104 77 Glycosaminoglycan biosynthesis - keratan sulfate 0.039424 12 23 Central carbon metabolism in cancer 0.04664 46 70 Melanogenesis 0.04852 68 76