COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile

Fulzele Sadanand, Sahay Bikash, Yusufu Ibrahim, Lee Tae Jin, Sharma Ashok, Kolhe Ravindra, Isales Carlos M

Table 6 Human miRNAs targeting the COVID-19 genome regulating GO pathway.

GO Category p-value #genes #miRNAs organelle 1.26E-49 980 64 ion binding 5.53E-28 611 64 cellular nitrogen compound metabolic process 1.82E-23 474 63 biosynthetic process 1.36E-13 388 42 neurotrophin TRK receptor signaling pathway 7.06E-13 44 44 protein binding transcription factor activity 1.83E-12 75 29 Fc-epsilon receptor signaling pathway 5.76E-12 32 24 protein complex 6.82E-11 385 64 gene expression 4.82E-10 70 35 cellular protein modification process 7.10E-10 232 41 molecular_function 7.10E-10 1552 66 extracellular matrix disassembly 1.72E-09 26 14 viral process 1.82E-09 60 49 symbiosis, encompassing mutualism through parasitism 1.82E-09 66 49 small molecule metabolic process 4.04E-09 229 57 catabolic process 1.70E-08 197 58 collagen catabolic process 3.52E-08 22 12 cellular component assembly 5.85E-08 141 36 cellular_component 7.90E-08 1559 66 macromolecular complex assembly 1.77E-07 101 36 blood coagulation 8.36E-07 55 26 nucleic acid binding transcription factor activity 1.97E-06 107 38 cytosol 3.58E-06 267 57 protein complex assembly 4.08E-06 88 48 epidermal growth factor receptor signaling pathway 1.64E-05 31 23 enzyme binding 1.92E-05 130 51 extracellular matrix organization 2.18E-05 51 21 nucleoplasm 2.49E-05 122 56 cellular protein metabolic process 3.33E-05 49 29 xenobiotic metabolic process 4.07E-05 23 21 immune system process 4.82E-05 160 36 nucleobase-containing compound catabolic process 6.69E-05 92 53 endoplasmic reticulum lumen 0.000154305 29 16 response to stress 0.000159934 210 39 innate immune response 0.000224462 80 28 microtubule organizing center 0.000453748 56 43 Fc-gamma receptor signaling pathway involved in phagocytosis 0.00093232 12 17 toll-like receptor TLR1:TLR2 signaling pathway 0.001615504 11 15 toll-like receptor TLR6:TLR2 signaling pathway 0.001615504 11 15 fibroblast growth factor receptor signaling pathway 0.001615504 26 23 mitotic cell cycle 0.001685088 39 45 glutathione derivative biosynthetic process 0.001906053 7 12 DNA metabolic process 0.00191818 79 34 biological_process 0.00191818 1484 66 phosphatidylinositol-mediated signaling 0.002737027 20 22 toll-like receptor 2 signaling pathway 0.005968204 12 17 cytoskeleton-dependent intracellular transport 0.007263134 17 15 toll-like receptor 4 signaling pathway 0.007263134 14 17 membrane organization 0.007346668 56 45 cellular response to jasmonic acid stimulus 0.007563711 3 1 cell motility 0.008091976 60 31 G2/M transition of mitotic cell cycle 0.010059905 20 36 cell-cell signaling 0.010959215 65 31 platelet degranulation 0.011941199 11 15 protein N-linked glycosylation via asparagine 0.012823473 14 14 homeostatic process 0.013223078 81 27 post-translational protein modification 0.013916886 18 20 toll-like receptor 10 signaling pathway 0.015857167 9 14 cell death 0.015857167 85 25 substrate-dependent cell migration, cell extension 0.018717628 5 9 nervous system development 0.019812789 51 26 toll-like receptor 9 signaling pathway 0.021790835 10 16 RNA binding 0.021790835 168 42 platelet activation 0.023223454 22 20 extracellular matrix structural constituent 0.034117778 16 4 transcription coactivator activity 0.034117778 41 23 cytoskeletal protein binding 0.036370846 71 34 toll-like receptor 5 signaling pathway 0.039177086 9 14 axon guidance 0.040371436 49 21 cAMP metabolic process 0.043778349 3 9 TRIF-dependent toll-like receptor signaling pathway 0.045227284 9 14