COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile

Fulzele Sadanand, Sahay Bikash, Yusufu Ibrahim, Lee Tae Jin, Sharma Ashok, Kolhe Ravindra, Isales Carlos M

Table 7 List of selected human miRNAs targeting the COVID-19 genome down-regulated with age and underlying conditions.

miRNA Decrease Expression in age related diseases (Human) Reference miR-15b-5p Coronary Artery Disease Zhu et al 2017 [37] miR-15a-5p Kidney disease Shang et al 2019 [38] miR-548c-5p Colorectal Cancer Peng et al 2018 [49] miR-548d-3p Osteosarcoma Chen et al 2019 [50] miR-409-3p Osteosarcoma Wu et al 2019 [51] miR-30b-5p Plasma (Aging) Hatse et al 2014 [52] miR-505-3p Prostate cancer Tang et al 2019 [53] miR-520c-3p Obesity/diabetes Ortega et al 2013 [39] miR-30e-3p Myocardial Injury Wang et al 2017 [40] miR-23c Hepatocellular carcinoma Zhang et al 2018 [41] miR-30d-5p Non-small cell lung cancer Gao et al, 2018 [42] miR-4684-3p Colorectal cancer Wu et al, 2015 [43] miR-518a-5p Gastrointestinal tumors Shi et al, 2016 [44]